Faculty Collaboration Database

Genetic association with rheumatoid arthritis-Genetic Analysis Workshop 15: summary of contributions from Group 2. Genet Epidemiol 2007;31 Suppl 1:S12-21

Date

11/30/2007

Pubmed ID

18046771

DOI

10.1002/gepi.20276

Scopus ID

2-s2.0-38049020986 (requires institutional sign-in at Scopus site)   5 Citations

Abstract

The papers in presentation group 2 of Genetic Analysis Workshop 15 (GAW15) conducted association analyses of rheumatoid arthritis data. The analyses were carried out primarily in the data provided by the North American Rheumatoid Arthritis Consortium (NARAC). One group conducted analyses in the data provided by the Canadian Rheumatoid Arthritis Genetics Study (CRAGS). Analysis strategies included genome-wide scans, the examination of candidate genes, and investigations of a region of interest on chromosome 18q21. Most authors employed relatively new methods, proposed extensions of existing methods, or introduced completely novel methods for aspects of association analysis. There were several common observations; a group of papers using a variety of methods found stronger association, on chromosomes 6 and 18 and in candidate gene PTPN22 among women with early onset. Generally, models that considered haplotypes or multiple markers showed stronger evidence for association than did single marker analyses.

Author List

Wilcox MA, Li Z, Tapper W, Browning S, Curtin K, Ding J, Ding Y, Gagnon F, He Q, Kuo TY, Li M, Matthew G, Mei L, Rao S, Shaw J, Wei Z, Yu Z, Zhang W, Zheng T, Zhu G

Author

Ling Mei MD Associate Professor in the Medicine department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Algorithms
Arthritis, Rheumatoid
Chromosomes, Human, Pair 18
Chromosomes, Human, Pair 6
Genome, Human
Haplotypes
Humans
Phenotype
Protein Tyrosine Phosphatase, Non-Receptor Type 22