Effect of transfusion on immune function in a traumatized animal model. Arch Surg 1986 Jan;121(1):50-5
Date
01/01/1986Pubmed ID
3484624DOI
10.1001/archsurg.1986.01400010056007Scopus ID
2-s2.0-0022623151 (requires institutional sign-in at Scopus site) 78 CitationsAbstract
Blood transfusions repeatedly have been shown to prolong allograft survival, probably by stimulating suppressor T lymphocytes. The effects of transfusions on immune function in traumatized patients has not previously been investigated. We investigated the effects of transfusions on the immune system using a burned rat model. The transfusions were found to have no effect on the white blood cell counts, differential cell count, or neutrophil migration and bactericidal index. Those animals that received transfusion did exhibit impaired cell-mediated immunity and macrophage migration. Blood transfusions seem to increase further the immunosuppression seen with trauma and surgery.
Author List
Waymack JP, Rapien J, Garnett D, Tweddell JS, Alexander JWMESH terms used to index this publication - Major topics in bold
AnimalsBlood Bactericidal Activity
Blood Cell Count
Blood Transfusion
Burns
Cell Movement
Colony-Forming Units Assay
Immunity, Cellular
Macrophages
Male
Neutrophils
Rats
Rats, Inbred Lew
Staphylococcus aureus
Transfusion Reaction
