Oncologic outcomes of extended neck dissections in human papillomavirus-related oropharyngeal squamous cell carcinoma. Head Neck 2018 May;40(5):955-962
Date
01/30/2018Pubmed ID
29377416DOI
10.1002/hed.25060Scopus ID
2-s2.0-85041130221 (requires institutional sign-in at Scopus site) 2 CitationsAbstract
BACKGROUND: Oncologic outcomes of human papillomavirus (HPV)-related oropharyngeal squamous cell carcinoma (SCC) requiring resection of major muscular or neurovascular tissue during neck dissection for invasive nodal disease remain uncertain.
METHODS: Patients with HPV-related oropharyngeal SCC requiring resection of major muscular or neurovascular tissue during their neck dissections were retrospectively identified.
RESULTS: Seventy-two patients were included. Regional and distant recurrences occurred in 6% and 17% of patients. Advanced T classification, pathological node number of 5 or more, and omission of adjuvant therapy were associated with decreased disease-free survival (DFS). The addition of adjuvant chemotherapy was not associated with improved survival.
CONCLUSION: Patients with invasive nodal disease from HPV-related oropharyngeal SCC can be managed with up-front surgery and adjuvant therapy, as indicated with good regional control. Although distant recurrence was the primary site of failure, adjuvant chemotherapy was not associated with improved outcomes. The T classification, node number, and adjuvant radiotherapy are independent prognostic factors in this patient population.
Author List
Zenga J, Pipkorn P, Graboyes EM, Martin EJ, Rich JT, Moore EJ, Haughey BH, Jackson RSAuthor
Joseph Zenga MD Chief, Associate Professor in the Otolaryngology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgedCarcinoma, Squamous Cell
Combined Modality Therapy
Disease-Free Survival
Female
Humans
Male
Middle Aged
Neck Dissection
Oropharyngeal Neoplasms
Papillomaviridae
Papillomavirus Infections
Retrospective Studies
Survival Rate
Treatment Outcome
