Faculty Collaboration Database

Poly(Pentafluorophenyl Methacrylate)-Based Nano-Objects Developed by Photo-PISA as Scaffolds for Post-Polymerization Functionalization. Macromol Rapid Commun 2019 Jan;40(2):e1800460

Date

08/01/2018

Pubmed ID

30062711

DOI

10.1002/marc.201800460

Scopus ID

2-s2.0-85059615997 (requires institutional sign-in at Scopus site)   51 Citations

Abstract

The preparation of a functional fluorine-containing block copolymer using reversible addition-fragmentation chain-transfer dispersion polymerization in DMSO as a "platform/scaffold" is explored. The nanostructures, comprised of poly(ethyleneglycol)-b-poly(pentafluorophenyl methacrylate) or PEG-b-P(PFMA), are formulated via photo-initiated polymerization-induced self-assembly (PISA) followed by post-polymerization modification using different primary amines. A combination of light scattering and microscopy techniques are used to characterize the resulting morphologies. It is found that upon varying the degree of polymerization of the core-forming block of PFMA, only uniform spheres (with textured surfaces) are obtained. These nanostructures are subsequently modified by cross-linking using a non-responsive and a redox-responsive diamine, thus imparting stability to the particles in water. In response to intracellular glutathione (GSH) concentration, destabilization of the micelles occurs as evidenced by dynamic light scattering. The well-defined size, inherent reactivity of the nanoparticles toward nucleophiles, and GSH-responsiveness of the nanospheres make them ideal scaffolds for drug delivery to intracellular compartments with reductive environments.

Author List

Couturaud B, Georgiou PG, Varlas S, Jones JR, Arno MC, Foster JC, O'Reilly RK

Author

Test W. User test user title in the Anesthesiology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Amines
Chemistry Techniques, Synthetic
Glutathione
Light
Methacrylates
Microscopy, Electron, Transmission
Models, Chemical
Molecular Structure
Nanostructures
Polymerization
Polymers
Water