Medical College of Wisconsin
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Advanced biomarkers of pediatric mild traumatic brain injury: Progress and perils. Neurosci Biobehav Rev 2018 Nov;94:149-165

Date

08/14/2018

Pubmed ID

30098989

Pubmed Central ID

PMC6221189

DOI

10.1016/j.neubiorev.2018.08.002

Scopus ID

2-s2.0-85053196299 (requires institutional sign-in at Scopus site)   71 Citations

Abstract

There is growing public concern about neurodegenerative changes (e.g., Chronic Traumatic Encephalopathy) that may occur chronically following clinically apparent and clinically silent (i.e., sub-concussive blows) pediatric mild traumatic brain injury (pmTBI). However, there are currently no biomarkers that clinicians can use to objectively diagnose patients or predict those who may struggle to recover. Non-invasive neuroimaging, electrophysiological and neuromodulation biomarkers have promise for providing evidence of the so-called "invisible wounds" of pmTBI. Our systematic review, however, belies that notion, identifying a relative paucity of high-quality, clinically impactful, diagnostic or prognostic biomarker studies in the sub-acute injury phase (36 studies on unique samples in 28 years), with the majority focusing on adolescent pmTBI. Ultimately, well-powered longitudinal studies with appropriate control groups, as well as standardized and clearly-defined inclusion criteria (time post-injury, injury severity and past history) are needed to truly understand the complex pathophysiology that is hypothesized (i.e., still needs to be determined) to exist during the acute and sub-acute stages of pmTBI and may underlie post-concussive symptoms.

Author List

Mayer AR, Kaushal M, Dodd AB, Hanlon FM, Shaff NA, Mannix R, Master CL, Leddy JJ, Stephenson D, Wertz CJ, Suelzer EM, Arbogast KB, Meier TB

Authors

Timothy B. Meier PhD Professor in the Neurosurgery department at Medical College of Wisconsin
Test W. User test user title in the Anesthesiology department at University of Wisconsin - Milwaukee




MESH terms used to index this publication - Major topics in bold

Animals
Biomarkers
Brain Concussion
Child
Humans
Meta-Analysis as Topic