Angioinvasive fungal infections impacting the skin: Diagnosis, management, and complications. J Am Acad Dermatol 2019 Apr;80(4):883-898.e2
Date
08/14/2018Pubmed ID
30102950DOI
10.1016/j.jaad.2018.04.058Scopus ID
2-s2.0-85062719184 (requires institutional sign-in at Scopus site) 31 CitationsAbstract
As discussed in the first article in this continuing medical education series, angioinvasive fungal infections pose a significant risk to immunocompromised and immunocompetent patients alike, with a potential for severe morbidity and high mortality. The first article in this series focused on the epidemiology and clinical presentation of these infections; this article discusses the diagnosis, management, and potential complications of these infections. The mainstay diagnostic tests (positive tissue culture with histologic confirmation) are often supplemented with serum biomarker assays and molecular testing (eg, quantitative polymerase chain reaction analysis and matrix-assisted laser desorption ionization time-of-flight mass spectrometry) to ensure proper speciation. When an angioinvasive fungal infection is suspected or diagnosed, further workup for visceral involvement also is essential and may partially depend on the organism. Different fungal organisms have varied susceptibilities to antifungal agents, and knowledge on optimal treatment regimens is important to avoid the potential complications associated with undertreated or untreated fungal infections.
Author List
Berger AP, Ford BA, Brown-Joel Z, Shields BE, Rosenbach M, Wanat KAAuthor
Karolyn A. Wanat MD Chair, Professor in the Dermatology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Antifungal AgentsBiomarkers
Biopsy, Needle
Blood Vessels
Combined Modality Therapy
Dermatomycoses
Drug Resistance, Fungal
Humans
Mycological Typing Techniques
Opportunistic Infections
Polymerase Chain Reaction
Skin
Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization
