Determining the Roles that Club Drugs, Marijuana, and Heavy Drinking Play in PrEP Medication Adherence Among Gay and Bisexual Men: Implications for Treatment and Research. AIDS Behav 2019 May;23(5):1277-1286
Date
10/12/2018Pubmed ID
30306433Pubmed Central ID
PMC6458096DOI
10.1007/s10461-018-2309-9Scopus ID
2-s2.0-85055266526 (requires institutional sign-in at Scopus site) 51 CitationsAbstract
Researchers have established that substance use interferes with anti-retroviral medication adherence among gay and bisexual men (GBM) living with HIV. There is limited parallel examination of pre-exposure prophylaxis (PrEP) adherence among HIV-negative GBM. We conducted retrospective 30-day timeline follow-back interviews and prospective semi-weekly diary data for 10 weeks with 104 PrEP-using GBM, half of whom engaged in club drug use (ketamine, ecstasy, GHB, cocaine, or methamphetamine)-generating 9532 days of data. Participants reported their day-by-day PrEP, club drug, marijuana, and heavy alcohol use (5 + drinks in one sitting). On average, club drug users were no more likely to miss a dose of PrEP than non-club drug users (M = 1.6 doses, SD = 3.0, past 30 days). However, we found that club drug use (at the event level) increased the odds of missing a dose on the same day by 55% and the next day (e.g., a "carryover effect") by 60%. Further, missing a dose on one day increased the odds of missing a dose the following day by eightfold. We did not identify an event-level effect of marijuana use or heavy drinking on PrEP adherence. Our data suggest club drug users could have greater protective effects from daily oral or long-acting injectable PrEP compared to a time-driven PrEP regimen because of the concurrence of club drug use and PrEP non-adherence.
Author List
Grov C, Rendina HJ, John SA, Parsons JTMESH terms used to index this publication - Major topics in bold
AdultAlcohol Drinking
Bisexuality
Drug Monitoring
Drug Users
HIV Infections
Homosexuality, Male
Humans
Male
Marijuana Smoking
Medication Adherence
Pre-Exposure Prophylaxis
Retrospective Studies
