Faculty Collaboration Database

18F-fluorodeoxyglucose-positron emission tomography and pathologic tumor size in early-stage invasive cervical cancer. Int J Gynecol Cancer 2009 Nov;19(8):1412-4

Date

12/17/2009

Pubmed ID

20009899

DOI

10.1111/IGC.0b013e3181b62e8c

Scopus ID

2-s2.0-73349110081 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

PURPOSE: Cervical cancer tumor size determined by 18F-fluorodeoxyglucose-positron emission tomography (FDG-PET) thresholding of the maximum standardized uptake value (SUVMax) has been correlated with the determined tumor size by computed tomography and magnetic resonance imaging. The purpose of this study was to evaluate the relationship between preoperative FDG-PET tumor size and pathologic tumor diameter in patients with early-stage cervical cancer who were undergoing radical hysterectomy.

PATIENTS AND METHODS: Forty patients with early-stage cervical cancer underwent pretreatment FDG-PET/computed tomography before radical hysterectomy and lymph node dissection. Primary tumor diameter was defined on FDG-PET as the largest diameter of the 3-dimensional volumetric isocontour of the 40% threshold of the SUVMax. The FDG-PET measurements were compared with the tumor diameter and the histological diameter of the pathologic specimen using regression analysis, paired t test, and unpaired t test.

RESULTS: The FDG-PET tumor diameter measurements were correlated to the pathologic tumor diameter in the surgical specimen with a coefficient of determination (R2) of 0.951 and a correlation coefficient of 0.757 (P < 0.0001).

CONCLUSION: There is a high level of correlation in the FDG-PET and the pathologic tumor measurements in the early-stage cervical cancer.

Author List

Showalter TN, Miller TR, Huettner P, Rader J, Grigsby PW

Author

Janet Sue Rader MD Chair, Professor in the Obstetrics and Gynecology department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Adenocarcinoma
Adult
Aged
Carcinoma, Squamous Cell
Cohort Studies
Female
Fluorodeoxyglucose F18
Humans
Magnetic Resonance Imaging
Middle Aged
Neoplasm Invasiveness
Neoplasm Staging
Positron-Emission Tomography
Prognosis
Prospective Studies
Radiopharmaceuticals
Tomography, X-Ray Computed
Uterine Cervical Neoplasms