Nodular lymphocyte predominant Hodgkin lymphoma with clusters of LP Cells, acute inflammation, and fibrosis: a syncytial variant. Am J Surg Pathol 2009 Nov;33(11):1725-31
Date
09/05/2009Pubmed ID
19730363DOI
10.1097/PAS.0b013e3181b27765Scopus ID
2-s2.0-70350441394 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) has clinicopathologic, immunophenotypic, and molecular features that are distinct from classical Hodgkin lymphoma (cHL). Distinguishing these entities is usually straightforward, but unusual variants of NLPHL have been described that can be problematic diagnostically and potentially have clinical significance. We describe a case of NLPHL showing a variant histologic pattern characterized by small and large clusters of lymphocyte predominance cells within nodules defined by follicular dendritic cell meshworks, associated with numerous neutrophils and areas of internodular fibrosis. Focally, the neoplastic cells had lacunar cell-like cytologic features. The resulting combination, not previously reported, closely mimicked the syncytial variant of nodular sclerosis cHL. After chemotherapy the patient was free of disease 14 years later. In our review of the literature we identified rare cases of NLPHL that had similar histologic features, but lacked the neutrophilic infiltration. Recognition of this rare variant, facilitated by immunohistochemical studies in this case, further expands the morphologic spectrum of NLPHL.
Author List
Drakos E, Rassidakis GZ, Leventaki V, Cotta CV, Vega F, Medeiros LJMESH terms used to index this publication - Major topics in bold
Acute DiseaseAdult
Antineoplastic Combined Chemotherapy Protocols
Biomarkers, Tumor
Bleomycin
Dacarbazine
Disease-Free Survival
Doxorubicin
Fibrosis
Hodgkin Disease
Humans
Immunohistochemistry
Lymph Nodes
Lymphadenitis
Lymphocytes
Lymphoma, Follicular
Male
Neutrophils
Radiotherapy, Adjuvant
Sclerosis
Vinblastine
