The Gene Ontology Resource: 20 years and still GOing strong. Nucleic Acids Res 2019 Jan 08;47(D1):D330-D338
Date
11/06/2018Pubmed ID
30395331Pubmed Central ID
PMC6323945DOI
10.1093/nar/gky1055Scopus ID
2-s2.0-85059799086 (requires institutional sign-in at Scopus site) 3396 CitationsAbstract
The Gene Ontology resource (GO; http://geneontology.org) provides structured, computable knowledge regarding the functions of genes and gene products. Founded in 1998, GO has become widely adopted in the life sciences, and its contents are under continual improvement, both in quantity and in quality. Here, we report the major developments of the GO resource during the past two years. Each monthly release of the GO resource is now packaged and given a unique identifier (DOI), enabling GO-based analyses on a specific release to be reproduced in the future. The molecular function ontology has been refactored to better represent the overall activities of gene products, with a focus on transcription regulator activities. Quality assurance efforts have been ramped up to address potentially out-of-date or inaccurate annotations. New evidence codes for high-throughput experiments now enable users to filter out annotations obtained from these sources. GO-CAM, a new framework for representing gene function that is more expressive than standard GO annotations, has been released, and users can now explore the growing repository of these models. We also provide the 'GO ribbon' widget for visualizing GO annotations to a gene; the widget can be easily embedded in any web page.
Author List
The Gene Ontology ConsortiumAuthors
Melinda R. Dwinell PhD Associate Dean, Professor in the Physiology department at Medical College of WisconsinStanley J. Laulederkind Research Scientist II in the Physiology department at Medical College of Wisconsin
Shur-Jen Wang Research Scientist II in the Physiology department at Medical College of Wisconsin
MESH terms used to index this publication - Major topics in bold
AnimalsBacteria
Eukaryota
Gene Ontology
High-Throughput Screening Assays
History, 20th Century
History, 21st Century
Humans
Mitogen-Activated Protein Kinases
Molecular Sequence Annotation
Quality Control
