Uncovering the Cells and Circuits of Touch in Normal and Pathological Settings. Neuron 2018 Oct 24;100(2):349-360
Date
10/26/2018Pubmed ID
30359601Pubmed Central ID
PMC6708582DOI
10.1016/j.neuron.2018.10.019Scopus ID
2-s2.0-85055049128 (requires institutional sign-in at Scopus site) 115 CitationsAbstract
The sense of touch is fundamental as it provides vital, moment-to-moment information about the nature of our physical environment. Primary sensory neurons provide the basis for this sensation in the periphery; however, recent work demonstrates that touch transduction mechanisms also occur upstream of the sensory neurons via non-neuronal cells such as Merkel cells and keratinocytes. Within the spinal cord, deep dorsal horn circuits transmit innocuous touch centrally and also transform touch into pain in the setting of injury. Here non-neuronal cells play a key role in the induction and maintenance of persistent mechanical pain. This review highlights recent advances in our understanding of mechanosensation, including a growing appreciation for the role of non-neuronal cells in both touch and pain.
Author List
Moehring F, Halder P, Seal RP, Stucky CLAuthor
Cheryl L. Stucky PhD Professor in the Cell Biology, Neurobiology and Anatomy department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsHumans
Mechanoreceptors
Mechanotransduction, Cellular
Neural Pathways
Touch
Touch Perception
