5-L-hydroxy-6,8,11,14-eicosatetraenoate potentiates the human neutrophil degranulating action of platelet-activating factor. Biochem Biophys Res Commun 1983 Feb 28;111(1):1-7
Date
02/28/1983Pubmed ID
6403011DOI
10.1016/s0006-291x(83)80108-9Scopus ID
2-s2.0-0020575512 (requires institutional sign-in at Scopus site) 48 CitationsAbstract
Platelet-activating factor (AAGPC) and two of its structural analogues degranulated human neutrophils with respective potencies that were increased up to 100 to 1000-fold by 16 nM to 5 microM of 5-L-hydroxyeicosatetraenoate (5-L-HETE). 5-rac-HETE had similar actions but 8-rac-HETE was without effect. Furthermore, 5-L-HETE did not influence the degranulating actions of C5a, A23187 or a formalated oligopeptide chemotactic factor and none of the HETEs, by themselves, caused degranulation. Thus, 5-L-HETE and AAGPC selectively interact to induce degranulation. Since these products rapidly form in stimulated PMNs, they may serve as potentiator and agonist, respectively, to transduce biological signals into cell function.
Author List
O'Flaherty JT, Thomas MJ, Hammett MJ, Carroll C, McCall CE, Wykle RLMESH terms used to index this publication - Major topics in bold
Arachidonic AcidsCalcimycin
Complement C5
Complement C5a
Drug Synergism
Glucuronidase
Humans
Hydroxyeicosatetraenoic Acids
Muramidase
N-Formylmethionine
N-Formylmethionine Leucyl-Phenylalanine
Neutrophils
Oligopeptides
Platelet Activating Factor
Time Factors
