Medical College of Wisconsin
CTSIResearch InformaticsREDCap

Lung injury in acute pancreatitis: primary inhibition of pulmonary phospholipid synthesis. Am J Surg 1987 Jan;153(1):54-61

Date

01/01/1987

Pubmed ID

3799893

DOI

10.1016/0002-9610(87)90201-7

Scopus ID

2-s2.0-0023088799 (requires institutional sign-in at Scopus site)   33 Citations

Abstract

Alterations in the pulmonary surfactant system are partly responsible for the respiratory insufficiency seen with acute pancreatitis. In this model of cerulein-induced pancreatitis in rats, we utilized a new stable isotope metabolic tracer technique to examine one aspect of the pulmonary surfactant system and its relationship to associated lung injury. We have demonstrated primary, early depression of lung phospholipid synthesis reflected in both lung tissue and alveolar washings. We suggest that this quantitative change in pulmonary surfactant synthetic rate may partly explain the occurrence of respiratory failure with acute pancreatitis.

Author List

Guice KS, Oldham KT, Wolfe RR, Simon RH

Author

Keith Oldham MD Emeritus Professor in the Surgery department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Acute Disease
Animals
Ceruletide
Lung Diseases
Male
Pancreatitis
Phosphatidylcholines
Phospholipids
Pulmonary Surfactants
Rats
Rats, Inbred Strains