Faculty Collaboration Database

Modeling of cellular metabolism and microcirculatory transport. Microcirculation 2008 Nov;15(8):777-93

Date

07/09/2008

Pubmed ID

18608987

DOI

10.1080/10739680802019709

Scopus ID

2-s2.0-52649174908 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Oxygen and other substrates, waste products, hormone messengers, and cells and other particles of the immune system are all transported in a closed-loop circulatory system in vertebrates, within which pumped blood travels to within diffusion distances of practically every cell in the body. Exchange of oxygen and carbon dioxide in the pulmonary capillaries and absorption of nutrients in the gut provide the circulating blood with biochemical reactants to sustain bioenergetic processes throughout the body. Inputs and outputs transported by the microcirculation are necessary to drive the open-system nonequilibrium chemical reactions of metabolism that are essential for cellular function. In turn, metabolically derived signals influence microcirculatory dynamics. Indeed, the microcirculation is the key system that ties processes at the whole-body level of the cardiovascular system to subcellular phenomena. This tight integration between cellular metabolism and microcirculatory transport begs for integrative simulations that span the cell, tissue, and organ scales.

Author List

Beard DA, Wu F, Cabrera ME, Dash RK

Author

Ranjan K. Dash PhD Professor in the Biomedical Engineering department at Medical College of Wisconsin

MESH terms used to index this publication - Major topics in bold

Animals
Biological Transport
Carbon Dioxide
Cells
Computer Simulation
Energy Metabolism
Hormones
Humans
Macromolecular Substances
Metabolic Networks and Pathways
Microcirculation
Models, Cardiovascular
Muscle, Skeletal
Oxygen
Systems Integration
Vertebrates
Xenobiotics