Successful high-dose intravenous cytarabine treatment of parenchymal brain involvement from malignant lymphoma. Arch Intern Med 1986 Apr;146(4):791-2
Date
04/01/1986Pubmed ID
3963961Scopus ID
2-s2.0-0022551774 (requires institutional sign-in at Scopus site) 21 CitationsAbstract
A patient with systemic recurrence of large-cell malignant lymphoma developed radiologic evidence of parenchymal brain metastasis. Treatment with systemic high-dose cytarabine resulted in complete regression of peripheral adenopathy and complete radiologic response in the central nervous system, with normalization of the brain computed tomographic scan. This case further demonstrates the ability of high-dose cytarabine to penetrate the blood-brain barrier and achieve therapeutic drug concentrations in the central nervous system, an area that might otherwise remain a pharmacologic sanctuary for tumor cells.
Author List
Frick JC, Hansen RM, Anderson T, Ritch PSMESH terms used to index this publication - Major topics in bold
Brain NeoplasmsCorpus Callosum
Cytarabine
Female
Frontal Lobe
Humans
Infusions, Parenteral
Lymphoma
Middle Aged
Spinal Neoplasms
