Faculty Collaboration Database

Renin secretion and loop of Henle chloride reabsorption in the adrenalectomized rat. Am J Physiol 1985 Oct;249(4 Pt 2):F596-602

Date

10/11/1985

Pubmed ID

3901779

DOI

10.1152/ajprenal.1985.249.4.F596

Scopus ID

2-s2.0-0022135371 (requires institutional sign-in at Scopus site)   11 Citations

Abstract

Renin release is increased in the adrenalectomized rat and is not inhibited by sodium chloride administration. The purpose of this study was to determine whether increased renin release is related to impaired absorptive chloride transport in the loop of Henle. Chloride transport in the loop was measured before and after acute saline infusion in three groups of rats: 1) saline-drinking adrenalectomized rats (Adx); 2) saline-drinking dexamethasone-treated adrenalectomized rats (Dex); and 3) water-drinking sham-operated controls. Unrelated to differences of arterial pressure, glomerular filtration rate, or net sodium chloride balance, chloride reabsorption in the loop of Henle of Adx [836 +/- 172 peq/min (SE)] was less (P less than 0.01) than in controls (1,646 +/- 353) and Dex (1,377 +/- 318) before saline infusion. After saline infusion, chloride delivery to the loop increased (P less than 0.05) in all three groups. However, loop chloride reabsorption increased (P less than 0.01) only in controls and Dex but not in Adx. Before saline infusion, plasma renin concentration (PRC) of Adx (350 +/- 108 U/ml) was greater (P less than 0.01) than that in controls (56 +/- 6) or Dex (108 +/- 36); sodium chloride infusion failed to inhibit PRC in Adx, whereas PRC was suppressed (P less than 0.01) by saline in Dex and controls. Thus stimulation of renin release in adrenalectomized animals was associated with decreased absorptive chloride transport in the loop of Henle. Dexamethasone normalized loop function and renin responsiveness to sodium chloride.

Author List

Welch WJ, Ott CE, Guthrie GP Jr, Kotchen TA

MESH terms used to index this publication - Major topics in bold

Absorption
Adrenal Glands
Adrenalectomy
Animals
Biological Transport, Active
Blood Pressure
Body Weight
Chlorides
Dexamethasone
Glomerular Filtration Rate
Hematocrit
Kidney Tubules
Loop of Henle
Rats
Rats, Inbred Strains
Renin
Sodium Chloride
Stimulation, Chemical