Polymorphisms of the tumor necrosis factor-alpha receptor 2 gene are associated with obesity phenotypes among 405 Caucasian nuclear families. Hum Genet 2008 Sep;124(2):171-7
Date
08/08/2008Pubmed ID
18685868Pubmed Central ID
PMC4176887DOI
10.1007/s00439-008-0536-2Scopus ID
2-s2.0-50649083462 (requires institutional sign-in at Scopus site) 4 CitationsAbstract
The plasma level of the tumor necrosis factor-alpha receptor 2 (TNFR2) is associated with obesity phenotypes. However, the genetic polymorphisms for such an association have rarely been explored and are generally unknown. In this study, by employing a large sample of 1,873 subjects from 405 Caucasian nuclear families, we explored the association of 12 SNPs of the TNFR2 gene and obesity-related phenotypes, including body mass index (BMI), fat mass, and percentage fat mass (PFM). The within-family quantitative transmission disequilibrium test, which is robust to sample stratification, was implemented to evaluate the association of TNFR2 gene with obesity phenotypes. Evidence of association was obtained at SNP9 (rs5746059) with fat mass (P = 0.0002), BMI (P = 0.002), and PFM (P = 0.0006). The contribution of this polymorphism to the variation of fat mass and PFM was 6.24 and 7.82%, respectively. Individuals carrying allele A at the SNP9 site had a 4.6% higher fat mass and a 2.5% increased PFM compared to noncarriers. The results remained significant even after correction for multiple testing. Evidence of association between the TNFR2 gene and obesity phenotypes are also found in 700 independent Chinese Han and 1,000 random Caucasians samples. The results suggest that the TNFR2 gene polymorphisms contribute to the variation of obesity phenotypes.
Author List
Zhao LJ, Xiong DH, Pan F, Liu XG, Recker RR, Deng HWMESH terms used to index this publication - Major topics in bold
AdultAged
Base Sequence
Female
Humans
Linkage Disequilibrium
Male
Middle Aged
Nuclear Family
Obesity
Phenotype
Polymorphism, Single Nucleotide
Receptors, Tumor Necrosis Factor, Type II
