Medical College of Wisconsin
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Repeated measurements of respiratory mechanics in developing rats utilizing a forced oscillation technique. Exp Lung Res 2008 Sep;34(7):409-23

Date

08/22/2008

Pubmed ID

18716927

DOI

10.1080/01902140802222084

Scopus ID

2-s2.0-50049122788 (requires institutional sign-in at Scopus site)   1 Citation

Abstract

The ability to successfully intubate the trachea of rats repeatedly over time, recover them, and perform repeated measures of changes in respiratory mechanics is important. The authors performed experiments utilizing 2 groups of rats at various ages in their development. Rats in the single-measurement group were studied at 1 age only. Rats in the repeated-measurement group were studied at each age point over time. Measurements of respiratory mechanics were made utilizing a forced-oscillation technique. We found no differences in respiratory mechanics between the 2 groups. Our results demonstrate that developing rats can be studied longitudinally to illustrate maturational changes in respiratory mechanics.

Author List

Heulitt MJ, Jones SM, Holt SJ, Thurman TL, Jo CH, Simpson PM

Author

Pippa M. Simpson PhD Adjunct Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Age Factors
Aging
Animals
Computer Simulation
Intubation, Intratracheal
Lung
Male
Models, Biological
Oscillometry
Rats
Rats, Sprague-Dawley
Respiratory Function Tests
Respiratory Mechanics