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Regression of genetically determined polycystic kidney disease in murine organ culture. Experientia 1986 Jan 15;42(1):77-80

Date

01/15/1986

Pubmed ID

3943602

DOI

10.1007/BF01975904

Scopus ID

2-s2.0-0022588314 (requires institutional sign-in at Scopus site)   15 Citations

Abstract

Cystic kidneys from the mutant CPK strain of C57BL/6J mice were cultured in serum-free organ culture. During 120 h of incubation in chemically-defined medium, CPK cystic tubular changes underwent complete regression. Environmental factors regulate the expression of genetically determined polycystic kidney disease in this model.

Author List

Avner ED, Sweeney WE Jr, Piesco NP, Ellis D

Author

Ellis D. Avner MD Emeritus Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Cell Survival
Culture Media
Kidney
Kidney Glomerulus
Kidney Tubules
Mice
Mice, Inbred C57BL
Mice, Mutant Strains
Organ Culture Techniques
Polycystic Kidney Diseases
Time Factors