David Baranger PhD

Research Areas of Interest
AdolescentAlcoholic IntoxicationAlcoholismBrainCannabisChildCognitionGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansLongitudinal StudiesMachine LearningMagnetic Resonance ImagingYoung AdultMethodologies and Techniques
AdolescentAdultAlcohol AbstinenceAlcohol DrinkingAlcoholic BeveragesAlcoholic IntoxicationAlcoholicsBrainCannabisChildGenome-Wide Association StudyHumansLongitudinal StudiesYoung AdultPublications (47)
Prenatal cannabis exposure, the brain, and psychopathology during early adolescence. (Baranger DA, Miller AP, Gorelik AJ, Paul SE, Hatoum AS, Johnson EC, Colbert SM, Smyser CD, Rogers CE, Bijsterbosch JD, Agrawal A, Bogdan R) Nat Ment Health 2024 Aug;2(8):975-986 PMID: 40836962 PMCID: PMC12363474 SCOPUS ID: 2-s2.0-85205275327 08/21/2025 12 CitationsMulti-ancestral genome-wide association study of clinically defined nicotine dependence reveals strong genetic correlations with other substance use disorders and health-related traits. (Johnson EC, Lai D, Balbona JV, Miller AP, Hatoum AS, Deak JD, Jennings M, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Adhikari K, Docherty AR, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries PW, Korhonen T, Morrison CL, Nunez YZ, Palviainen T, Su MH, Romero Villela PN, Wetherill L, Willoughby EA, Zellers SM, Bierut LJ, Buchwald J, Copeland WE, Corley RP, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio J, Keller MC, Lee JJ, Lind P, Madden PA, Maes HHM, Martin NG, McGue M, Medland SE, Nelson EC, Pearson J, Porjesz B, Stallings MC, Vrieze S, Wilhelmson KC, Kranzler HR, Walters RK, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A) Psychol Med 2025 Aug 20;55:e234 PMID: 40831304 PMCID: PMC12360691 SCOPUS ID: 2-s2.0-105013552891 08/20/2025 1 CitationPsychiatric genome-wide association study enrichment shows promise for future psychopharmaceutical discoveries. (Hatoum AS, Gorelik AJ, Blaydon L, Huggett SB, Chi T, Baranger DAA, Miller AP, Johnson EC, Agrawal A, Bogdan R) Commun Med (Lond) 2025 May 16;5(1):176 PMID: 40379965 PMCID: PMC12084526 SCOPUS ID: 2-s2.0-105005414041 05/17/2025 A Phenome-Wide association study (PheWAS) of genetic risk for C-reactive protein in children of European Ancestry: Results from the ABCD study. (Norton SA, Gorelik AJ, Paul SE, Johnson EC, Baranger DA, Siudzinski JL, Li ZA, Bondy E, Modi H, Karcher NR, Hershey T, Hatoum AS, Agrawal A, Bogdan R) Brain Behav Immun 2025 Aug;128:487-496 PMID: 40228565 PMCID: PMC12264583 SCOPUS ID: 2-s2.0-105003868963 04/15/2025 Enhancing task fMRI individual difference research with neural signatures. (Baranger DA, Gorelik AJ, Paul SE, Hatoum AS, Dosenbach N, Bogdan R) medRxiv 2025 Jan 31 PMID: 39974058 PMCID: PMC11838658 02/20/2025 Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence. (Miller AP, Baranger DAA, Paul SE, Garavan H, Mackey S, Tapert SF, LeBlanc KH, Agrawal A, Bogdan R) JAMA Netw Open 2024 Dec 02;7(12):e2452027 PMID: 39786408 PMCID: PMC11686416 SCOPUS ID: 2-s2.0-85214355662 01/09/2025 21 CitationsAssociations between prenatal caffeine exposure and child development: Longitudinal results from the Adolescent Brain Cognitive Development (ABCD) Study. (Modi H, Baranger DAA, Paul SE, Gorelik AJ, Hornstein A, Balbona JV, Agrawal A, Bijsterbosch JD, Bogdan R) Neurotoxicol Teratol 2025;107:107404 PMID: 39592017 PMCID: PMC12226004 SCOPUS ID: 2-s2.0-85212536960 11/27/2024 1 CitationA phenome-wide association study of cross-disorder genetic liability in youth genetically similar to individuals from European reference populations (Paul SE, Colbert SMC, Gorelik AJ, Johnson EC, Hatoum AS, Baranger DAA, Hansen IS, Nagella I, Blaydon L, Hornstein A, Elsayed NM, Barch DM, Bogdan R, Karcher NR) Nature Mental Health November 2024;2(11):1327-1341 SCOPUS ID: 2-s2.0-105011638715 11/01/2024 2 CitationsAssociations between polygenic scores for cognitive and non-cognitive factors of educational attainment and measures of behavior, psychopathology, and neuroimaging in the adolescent brain cognitive development study. (Gorelik AJ, Paul SE, Miller AP, Baranger DAA, Lin S, Zhang W, Elsayed NM, Modi H, Addala P, Bijsterbosch J, Barch DM, Karcher NR, Hatoum AS, Agrawal A, Bogdan R, Johnson EC) Psychol Med 2024 Oct 23;54(13):1-15 PMID: 39440454 PMCID: PMC11536102 SCOPUS ID: 2-s2.0-85207898548 10/23/2024 1 CitationKappa opioids inhibit spinal output neurons to suppress itch. (Sheahan TD, Warwick CA, Cui AY, Baranger DAA, Perry VJ, Smith KM, Manalo AP, Nguyen EK, Koerber HR, Ross SE) Sci Adv 2024 Sep 27;10(39):eadp6038 PMID: 39321286 PMCID: PMC11423883 SCOPUS ID: 2-s2.0-85204941573 09/25/2024 12 CitationsCross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking. (Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A) Neuropsychopharmacology 2024 Oct;49(11):1655-1665 PMID: 38906991 PMCID: PMC11399264 SCOPUS ID: 2-s2.0-85195662883 06/22/2024 11 CitationsAlcohol milestones and internalizing, externalizing, and executive function: longitudinal and polygenic score associations. (Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R) Psychol Med 2024 Jul;54(10):2644-2657 PMID: 38721768 PMCID: PMC11464200 SCOPUS ID: 2-s2.0-85193597446 05/09/2024 4 CitationsEvaluating Evidence Supporting an Effect of Prenatal Cannabis Exposure on White Matter Integrity. (Baranger DAA) Biol Psychiatry Glob Open Sci 2024 Jan;4(1):101-102 PMID: 38298795 PMCID: PMC10829662 SCOPUS ID: 2-s2.0-85182383310 02/01/2024 4 CitationsIdentification of a convergent spinal neuron population that encodes itch. (Sheahan TD, Warwick CA, Cui AY, Baranger DAA, Perry VJ, Smith KM, Manalo AP, Nguyen EK, Koerber HR, Ross SE) bioRxiv 2023 Nov 08 PMID: 37873278 PMCID: PMC10592866 10/24/2023 Alcohol use and grey matter structure: Disentangling predispositional and causal contributions in human studies. (Baranger DAA, Paul SE, Hatoum AS, Bogdan R) Addict Biol 2023 Sep;28(9):e13327 PMID: 37644894 PMCID: PMC10502907 SCOPUS ID: 2-s2.0-85168939950 08/30/2023 6 CitationsReliability of diurnal salivary cortisol metrics: A meta-analysis and investigation in two independent samples. (Norton SA, Baranger DA, Young ES, Voss M, Hansen I, Bondy E, Rodrigues M, Paul SE, Edershile E, Hill PL, Oltmanns TF, Simpson J, Bogdan R) Compr Psychoneuroendocrinol 2023 Nov;16:100191 PMID: 37635863 PMCID: PMC10458689 SCOPUS ID: 2-s2.0-85168343022 08/28/2023 4 CitationsTutorial: Power analyses for interaction effects in cross-sectional regressions. (Baranger DAA, Finsaas MC, Goldstein BL, Vize CE, Lynam DR, Olino TM) Adv Methods Pract Psychol Sci 2023;6(3) PMID: 40799847 PMCID: PMC12341451 SCOPUS ID: 2-s2.0-85173916347 07/01/2023 116 CitationsCharacteristics Associated With Cannabis Use Initiation by Late Childhood and Early Adolescence in the Adolescent Brain Cognitive Development (ABCD) Study. (Miller AP, Baranger DAA, Paul SE, Hatoum AS, Rogers C, Bogdan R, Agrawal A) JAMA Pediatr 2023 Aug 01;177(8):861-863 PMID: 37358866 PMCID: PMC10294012 SCOPUS ID: 2-s2.0-85166737198 06/26/2023 5 CitationsMultivariate genome-wide association meta-analysis of over 1 million subjects identifies loci underlying multiple substance use disorders. (Hatoum AS, Colbert SMC, Johnson EC, Huggett SB, Deak JD, Pathak G, Jennings MV, Paul SE, Karcher NR, Hansen I, Baranger DAA, Edwards A, Grotzinger A, Substance Use Disorder Working Group of the Psychiatric Genomics Consortium, Tucker-Drob EM, Kranzler HR, Davis LK, Sanchez-Roige S, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A) Nat Ment Health 2023 Mar;1(3):210-223 PMID: 37250466 PMCID: PMC10217792 SCOPUS ID: 2-s2.0-85218232859 05/30/2023 153 CitationsA Phenome-Wide Association Study (PheWAS) of Late Onset Alzheimer Disease Genetic Risk in Children of European Ancestry at Middle Childhood: Results from the ABCD Study. (Gorelik AJ, Paul SE, Karcher NR, Johnson EC, Nagella I, Blaydon L, Modi H, Hansen IS, Colbert SMC, Baranger DAA, Norton SA, Spears I, Gordon B, Zhang W, Hill PL, Oltmanns TF, Bijsterbosch JD, Agrawal A, Hatoum AS, Bogdan R) Behav Genet 2023 May;53(3):249-264 PMID: 37071275 PMCID: PMC10309061 SCOPUS ID: 2-s2.0-85153037626 04/19/2023 2 CitationsMulti-omics cannot replace sample size in genome-wide association studies. (Baranger DAA, Hatoum AS, Polimanti R, Gelernter J, Edenberg HJ, Bogdan R, Agrawal A) Genes Brain Behav 2023 Dec;22(6):e12846 PMID: 36977197 PMCID: PMC10733567 SCOPUS ID: 2-s2.0-85152062904 03/29/2023 7 CitationsPhenome-wide Investigation of Behavioral, Environmental, and Neural Associations with Cross-Disorder Genetic Liability in Youth of European Ancestry. (Paul SE, Colbert SMC, Gorelik AJ, Hansen IS, Nagella I, Blaydon L, Hornstein A, Johnson EC, Hatoum AS, Baranger DAA, Elsayed NM, Barch DM, Bogdan R, Karcher NR) medRxiv 2023 Feb 14 PMID: 36824847 PMCID: PMC9949197 02/25/2023 Characterizing Alcohol Expectancies in the ABCD Study: Associations with Sociodemographic Factors, the Immediate Social Environment, and Genetic Propensities. (Johnson EC, Paul SE, Baranger DAA, Hatoum AS, Colbert SMC, Lin S, Wolff R, Gorelik AJ, Hansen I, Karcher NR, Bogdan R, Agrawal A) Behav Genet 2023 May;53(3):265-278 PMID: 36662388 PMCID: PMC10159951 SCOPUS ID: 2-s2.0-85146567692 01/21/2023 3 CitationsAssociation of Mental Health Burden With Prenatal Cannabis Exposure From Childhood to Early Adolescence: Longitudinal Findings From the Adolescent Brain Cognitive Development (ABCD) Study. (Baranger DAA, Paul SE, Colbert SMC, Karcher NR, Johnson EC, Hatoum AS, Bogdan R) JAMA Pediatr 2022 Dec 01;176(12):1261-1265 PMID: 36094599 PMCID: PMC9468940 SCOPUS ID: 2-s2.0-85138229683 09/13/2022 34 CitationsModeration effects in personality disorder research. (Vize CE, Baranger DAA, Finsaas MC, Goldstein BL, Olino TM, Lynam DR) Personal Disord 2023 Jan;14(1):118-126 PMID: 35737564 PMCID: PMC9990702 SCOPUS ID: 2-s2.0-85133137046 06/24/2022 19 CitationsProtocol for a machine learning algorithm predicting depressive disorders using the T1w/T2w ratio. (Baranger DAA, Halchenko YO, Satz S, Ragozzino R, Iyengar S, Swartz HA, Manelis A) MethodsX 2021;8:101595 PMID: 35004227 PMCID: PMC8720909 SCOPUS ID: 2-s2.0-85120460066 01/11/2022 3 CitationsAberrant levels of cortical myelin distinguish individuals with depressive disorders from healthy controls. (Baranger DAA, Halchenko YO, Satz S, Ragozzino R, Iyengar S, Swartz HA, Manelis A) Neuroimage Clin 2021;32:102790 PMID: 34455188 PMCID: PMC8406024 SCOPUS ID: 2-s2.0-85113629662 08/30/2021 23 CitationsPsychotic-like Experiences and Polygenic Liability in the Adolescent Brain Cognitive Development Study. (Karcher NR, Paul SE, Johnson EC, Hatoum AS, Baranger DAA, Agrawal A, Thompson WK, Barch DM, Bogdan R) Biol Psychiatry Cogn Neurosci Neuroimaging 2022 Jan;7(1):45-55 PMID: 34271214 PMCID: PMC8786267 SCOPUS ID: 2-s2.0-85122175297 07/17/2021 40 CitationsPolygenic risk scores for alcohol involvement relate to brain structure in substance-naïve children: Results from the ABCD study. (Hatoum AS, Johnson EC, Baranger DAA, Paul SE, Agrawal A, Bogdan R) Genes Brain Behav 2021 Jun 06:e12756 PMID: 34092032 PMCID: PMC8645657 SCOPUS ID: 2-s2.0-85108826307 06/07/2021 13 CitationsThe longitudinal stability of fMRI activation during reward processing in adolescents and young adults. (Baranger DAA, Lindenmuth M, Nance M, Guyer AE, Keenan K, Hipwell AE, Shaw DS, Forbes EE) Neuroimage 2021 May 15;232:117872 PMID: 33609668 PMCID: PMC8238413 SCOPUS ID: 2-s2.0-85101550207 02/21/2021 23 CitationsNeuroticism and reward-related ventral striatum activity: Probing vulnerability to stress-related depression. (Bondy E, Baranger DAA, Balbona J, Sputo K, Paul SE, Oltmanns TF, Bogdan R) J Abnorm Psychol 2021 Apr;130(3):223-235 PMID: 33539118 PMCID: PMC8110089 SCOPUS ID: 2-s2.0-85104900340 02/05/2021 19 CitationsA large-scale genome-wide association study meta-analysis of cannabis use disorder. (Johnson EC, Demontis D, Thorgeirsson TE, Walters RK, Polimanti R, Hatoum AS, Sanchez-Roige S, Paul SE, Wendt FR, Clarke TK, Lai D, Reginsson GW, Zhou H, He J, Baranger DAA, Gudbjartsson DF, Wedow R, Adkins DE, Adkins AE, Alexander J, Bacanu SA, Bigdeli TB, Boden J, Brown SA, Bucholz KK, Bybjerg-Grauholm J, Corley RP, Degenhardt L, Dick DM, Domingue BW, Fox L, Goate AM, Gordon SD, Hack LM, Hancock DB, Hartz SM, Hickie IB, Hougaard DM, Krauter K, Lind PA, McClintick JN, McQueen MB, Meyers JL, Montgomery GW, Mors O, Mortensen PB, Nordentoft M, Pearson JF, Peterson RE, Reynolds MD, Rice JP, Runarsdottir V, Saccone NL, Sherva R, Silberg JL, Tarter RE, Tyrfingsson T, Wall TL, Webb BT, Werge T, Wetherill L, Wright MJ, Zellers S, Adams MJ, Bierut LJ, Boardman JD, Copeland WE, Farrer LA, Foroud TM, Gillespie NA, Grucza RA, Harris KM, Heath AC, Hesselbrock V, Hewitt JK, Hopfer CJ, Horwood J, Iacono WG, Johnson EO, Kendler KS, Kennedy MA, Kranzler HR, Madden PAF, Maes HH, Maher BS, Martin NG, McGue M, McIntosh AM, Medland SE, Nelson EC, Porjesz B, Riley BP, Stallings MC, Vanyukov MM, Vrieze S, Psychiatric Genomics Consortium Substance Use Disorders Workgroup, Davis LK, Bogdan R, Gelernter J, Edenberg HJ, Stefansson K, Børglum AD, Agrawal A) Lancet Psychiatry 2020 Dec;7(12):1032-1045 PMID: 33096046 PMCID: PMC7674631 SCOPUS ID: 2-s2.0-85095443055 10/24/2020 239 CitationsBorderline Personality Traits Are Not Correlated With Brain Structure in Two Large Samples. (Baranger DAA, Few LR, Sheinbein DH, Agrawal A, Oltmanns TF, Knodt AR, Barch DM, Hariri AR, Bogdan R) Biol Psychiatry Cogn Neurosci Neuroimaging 2020 Jul;5(7):669-677 PMID: 32312691 PMCID: PMC7360105 SCOPUS ID: 2-s2.0-85083318108 04/22/2020 18 CitationsConvergent Evidence for Predispositional Effects of Brain Gray Matter Volume on Alcohol Consumption. (Baranger DAA, Demers CH, Elsayed NM, Knodt AR, Radtke SR, Desmarais A, Few LR, Agrawal A, Heath AC, Barch DM, Squeglia LM, Williamson DE, Hariri AR, Bogdan R) Biol Psychiatry 2020 Apr 01;87(7):645-655 PMID: 31699293 PMCID: PMC7412715 SCOPUS ID: 2-s2.0-85075442976 11/09/2019 44 CitationsEditorial: Causal, Predispositional, or Correlate? Group Differences in Cognitive Control-Related Brain Function in Cannabis-Using Youth Raise New Questions. (Baranger DAA, Bogdan R) J Am Acad Child Adolesc Psychiatry 2019 Jul;58(7):665-667 PMID: 31150755 SCOPUS ID: 2-s2.0-85067408666 06/01/2019 4 CitationsGenetic Predisposition vs Individual-Specific Processes in the Association Between Psychotic-like Experiences and Cannabis Use. (Karcher NR, Barch DM, Demers CH, Baranger DAA, Heath AC, Lynskey MT, Agrawal A) JAMA Psychiatry 2019 Jan 01;76(1):87-94 PMID: 30347017 PMCID: PMC6400636 SCOPUS ID: 2-s2.0-85055182771 10/23/2018 47 CitationsMetabotropic Glutamate Receptor 2/3 (mGluR2/3) Activation Suppresses TRPV1 Sensitization in Mouse, But Not Human, Sensory Neurons. (Sheahan TD, Valtcheva MV, McIlvried LA, Pullen MY, Baranger DAA, Gereau RW 4th) eNeuro 2018;5(2) PMID: 29662945 PMCID: PMC5898698 SCOPUS ID: 2-s2.0-85046466108 04/18/2018 33 CitationsPolygenic Risk Scores in Clinical Psychology: Bridging Genomic Risk to Individual Differences. (Bogdan R, Baranger DAA, Agrawal A) Annu Rev Clin Psychol 2018 May 07;14:119-157 PMID: 29579395 PMCID: PMC7772939 SCOPUS ID: 2-s2.0-85042518900 03/27/2018 114 CitationsGenome-wide association study identifies a novel locus for cannabis dependence. (Agrawal A, Chou YL, Carey CE, Baranger DAA, Zhang B, Sherva R, Wetherill L, Kapoor M, Wang JC, Bertelsen S, Anokhin AP, Hesselbrock V, Kramer J, Lynskey MT, Meyers JL, Nurnberger JI, Rice JP, Tischfield J, Bierut LJ, Degenhardt L, Farrer LA, Gelernter J, Hariri AR, Heath AC, Kranzler HR, Madden PAF, Martin NG, Montgomery GW, Porjesz B, Wang T, Whitfield JB, Edenberg HJ, Foroud T, Goate AM, Bogdan R, Nelson EC) Mol Psychiatry 2018 May;23(5):1293-1302 PMID: 29112194 PMCID: PMC5938138 SCOPUS ID: 2-s2.0-85046756597 11/08/2017 34 CitationsPerceived stress is associated with increased rostral middle frontal gyrus cortical thickness: a family-based and discordant-sibling investigation. (Michalski LJ, Demers CH, Baranger DAA, Barch DM, Harms MP, Burgess GC, Bogdan R) Genes Brain Behav 2017 Nov;16(8):781-789 PMID: 28749606 PMCID: PMC5677535 SCOPUS ID: 2-s2.0-85028937895 07/28/2017 50 CitationsAn earlier time of scan is associated with greater threat-related amygdala reactivity. (Baranger DAA, Margolis S, Hariri AR, Bogdan R) Soc Cogn Affect Neurosci 2017 Aug 01;12(8):1272-1283 PMID: 28379578 PMCID: PMC5597858 SCOPUS ID: 2-s2.0-85032838219 04/06/2017 7 CitationsPER1 rs3027172 Genotype Interacts with Early Life Stress to Predict Problematic Alcohol Use, but Not Reward-Related Ventral Striatum Activity. (Baranger DA, Ifrah C, Prather AA, Carey CE, Corral-Frías NS, Drabant Conley E, Hariri AR, Bogdan R) Front Psychol 2016;7:464 PMID: 27065929 PMCID: PMC4814479 SCOPUS ID: 2-s2.0-84961990465 04/12/2016 33 CitationsGenetic Moderation of Stress Effects on Corticolimbic Circuitry. (Bogdan R, Pagliaccio D, Baranger DA, Hariri AR) Neuropsychopharmacology 2016 Jan;41(1):275-96 PMID: 26189450 PMCID: PMC4677127 SCOPUS ID: 2-s2.0-84949570889 07/21/2015 42 CitationsDecomposition of brain diffusion imaging data uncovers latent schizophrenias with distinct patterns of white matter anisotropy. (Arnedo J, Mamah D, Baranger DA, Harms MP, Barch DM, Svrakic DM, de Erausquin GA, Cloninger CR, Zwir I) Neuroimage 2015 Oct 15;120:43-54 PMID: 26151103 SCOPUS ID: 2-s2.0-84938099976 07/08/2015 43 CitationsStress-related anhedonia is associated with ventral striatum reactivity to reward and transdiagnostic psychiatric symptomatology. (Corral-Frías NS, Nikolova YS, Michalski LJ, Baranger DA, Hariri AR, Bogdan R) Psychol Med 2015;45(12):2605-17 PMID: 25853627 PMCID: PMC4700837 SCOPUS ID: 2-s2.0-84938750924 04/09/2015 107 CitationsDISC1 and SLC12A2 interaction affects human hippocampal function and connectivity. (Callicott JH, Feighery EL, Mattay VS, White MG, Chen Q, Baranger DA, Berman KF, Lu B, Song H, Ming GL, Weinberger DR) J Clin Invest 2013 Jul;123(7):2961-4 PMID: 23921125 PMCID: PMC3999052 SCOPUS ID: 2-s2.0-84879623565 08/08/2013 27 CitationsSmoking withdrawal is associated with increases in brain activation during decision making and reward anticipation: a preliminary study. (Addicott MA, Baranger DA, Kozink RV, Smoski MJ, Dichter GS, McClernon FJ) Psychopharmacology (Berl) 2012 Jan;219(2):563-73 PMID: 21766170 PMCID: PMC4140396 SCOPUS ID: 2-s2.0-84856681078 07/19/2011 41 Citations Last update: 10/10/2025