CURRICULUM VITAE
Andrew Spearman MD
Andrew Spearman MD
Associate Professor
Department of Pediatrics
Division of Cardiology
Department of Pediatrics
Division of Cardiology
OFFICE ADDRESS: |
Children’s Wisconsin - Milwaukee Hospital |
8915 W Connell Court |
Milwaukee, WI 53226 |
Email: aspearman@mcw.edu |
EDUCATION: |
2004 - 2008 BS, Biology, The Ohio State University, Columbus, OH |
2008 - 2012 MD, New York University School of Medicine, New York, NY |
POSTGRADUATE TRAINING AND FELLOWSHIP APPOINTMENTS: |
2012 - 2015 Pediatric Residency, University of Chicago, Chicago, IL |
2015 - 2018 Pediatric Cardiology Fellowship, Medical College of Wisconsin, Milwaukee, WI |
2018 - 2019 Post-Doctoral Research Fellowship, Vascular Biology, Medical College of Wisconsin, Milwaukee, WI |
2021 - 2023 Clinical Research Scholars Program, Clinical and Translational Science Institute, Medical College of Wisconsin, Milwaukee, WI |
FACULTY APPOINTMENTS: |
2018 - 2019 Instructor, Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI |
2019 - 2024 Assistant Professor, Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI |
2024 - Present Associate Professor, Department of Pediatrics, Division of Cardiology, Medical College of Wisconsin, Milwaukee, WI |
SPECIALTY BOARDS AND CERTIFICATION: |
Board Certified | Issue Date | Expiration |
American Board of Pediatrics | 2015 | None |
American Board of Pediatrics, Subspecialty Board for Cardiology | 2018 | None |
AWARDS AND HONORS: |
2021 - 2022 Teaching Pin, Outstanding medical student teacher award, Medical College of Wisconsin |
2022 - 2023 Teaching Pin, Outstanding medical student teacher award, Medical College of Wisconsin |
2023 - 2024 Teaching Pin, Outstanding graduate school educator award, Medical College of Wisconsin |
2024 Outstanding Teacher Award, Medical College of Wisconsin, Pediatric Cardiology Fellowship |
2024 Early Career Investigator Award, American Heart Association, Young Hearts Council |
MEMBERSHIPS IN HONORARY AND PROFESSIONAL SOCIETIES: |
2012 - 2020 American Academy of Pediatrics |
2018 - Present American Heart Association |
2020 - Present North American Vascular Biology Organization (NAVBO) |
EDITORSHIPS/EDITORIAL BOARDS/JOURNAL REVIEWS: |
Journal Review |
2018 - Present World Journal for Pediatric and Congenital Heart Surgery |
2019 - Present American Journal of Physiology - Heart and Circulatory Physiology |
2019 - Present Journal of the American Heart Association |
2019 - Present Cardiology in the Young |
2020 - Present PLOS ONE |
2021 - Present Journal of Molecular Medicine |
2022 - Present Frontiers in Cell and Developmental Biology |
2022 - Present Pediatric Cardiology |
2023 - Present Circulation |
2023 - Present Journal of Clinical Investigation |
2023 - Present Journal of Thoracic and Cardiovascular Surgery |
2023 - Present Scientific Reports |
2023 - Present Circulation: Cardiovascular Imaging |
2024 - Present Arteriosclerosis, Thrombosis, and Vascular Biology |
NATIONAL ELECTED/APPOINTED LEADERSHIP AND COMMITTEE POSITIONS: |
2020 Grant Reviewer, National Clinical and Translational Science Awards Program, NIH, National Center for Advancing Translational Sciences (NCATS) |
2022 Grant Reviewer, Single Ventricle Research Fund Review Committee, Additional Ventures |
2022 - 2023 Grant reviewer, Catalyst to Independence Award Review Committee, Additional Ventures |
2022 - 2024 Letter of Intent Reviewer, Collaborative Science Awards, American Heart Association |
2023 Early Career Reviewer (Ad hoc), Cardiac Differentiation and Development (CDD) study section, NIH |
2024 Grant Reviewer, Collaborative Science Award in Single Ventricle Heart Disease Grant Review Committee, American Heart Association & Additional Ventures |
2025 Grant Reviewer, Single Ventricle Research Fund, Additional Ventures |
2025 Full Application Committee Reviewer, Collaborative Science Award, American Heart Assocation |
RESEARCH GRANTS/AWARDS/CONTRACTS/PROJECTS: | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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INVITED LECTURES/WORKSHOPS/PRESENTATIONS: |
International |
Pulmonary arteriovenous malformations: a translational research perspective, Vasculata, North American Vascular Biology Association, Milwaukee, WI, 2019 |
Local |
Clinical Case Presenation, S. Bert Litwin Lectureship, Children's Wisconsin, Milwaukee, WI, 2016 |
Adverse early life environment increases mRNA expression of genes involved in cardiac fibrosis, Children's Research Institute, Children's Wisconsin, Milwaukee, WI, 2017 |
Adverse maternal environment increases susceptibility to insulin resistance and cardiac fibrosis in adult mice, Children's Research Institute, Children's Wisconsin, Milwaukee, WI, 2018 |
Clinical Case Presentation, William Gallen Lectureship, Children's Wisconsin, Milwaukee, WI, 2018 |
Pulmonary arteriovenous malformations: a translational research perspective, William Gallen Lectureship, Children's Wisconsin, Milwaukee, WI, 2019 |
Hepatic factor and pulmonary AVMs: What do we know?, Herma Heart Institute - Quality, Outcomes, Research Seminar Series, Children's Wisconsin, Milwaukee, WI, 2020 |
Pulmonary AVMs in palliated single ventricle congenital heart disease, Children's Research Institute Research Conference, Children's Wisconsin, Milwaukee, WI, 2020 |
Hepatopulmonary signaling and pulmonary AVMs in congenital heart disease, MCW Cardiovascular Center Seminar Series, Milwaukee, WI, 2021 |
Pulmonary AVMs in congenital heart disease, MCW Department of Pediatrics Scholarship in Progress, Milwaukee, WI, 2022 |
Aortopulmonary collaterals - when, where, and how?, Herma Heart Institute - Quality, Outcomes, Research Seminar Series, Children's Wisconsin, Milwaukee, WI, 2022 |
Endothelial cell polarization & vascular homeostasis, Children's Research Institute Research Conference, Children's Wisconsin, Milwaukee, WI, 2022 |
PEER REVIEWED WORKSHOPS/PRESENTATIONS: |
International |
Spearman AD, Linder JR, Williams P, Pediatric resident ECG interpretation and intervention abilities, Pediatric Academic Societies Meeting, San Diego, CA, 2015 |
Spearman AD, Ke X, Fu Q, Lane RH, Majnik A, Adverse early life environment increases mRNA expression of genes involved in cardiac fibrosis., Pediatric Academic Societies Meeting, San Francisco, CA, 2017 |
Spearman AD, Ke X, Fu Q, Lane RH, Majnik A., Adverse maternal environment increases susceptibility to cardiac fibrosis in adult mice, Pediatric Academic Societies Meeting, Toronto, Ontario, 2018 |
National |
Spearman AD, Loomba RS, Danduran M, Kovach J., Intrauterine growth restriction is not associated with decreased exercise capacity in adolescents with congenital heart disease, American Academy of Pediatrics National Conference & Exhibition, Chicago, IL, 2017 |
Spearman AD, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R, Superior vena cava blood up-regulates RNA expression of vascular remodeling pathways in lung endothelial cells, American Heart Association Scientific Sessions, Virtual meeting, 11/2021 - Present |
Regional |
Van Galder H, Schaal AM, Feng M, Pan AY, Frommelt MA, Ginde S, Spearman AD, Investigating susceptibility to pulmonary arteriovenous malformations prior to Fontan palliation in heterotaxy, Midwest Pediatric Cardiology Meeting, Virtual Meeting, 2020 |
Calley BJ, Pan AY, Liegl MN, Zhang L, Kindel SJ, Ginde S, Spearman AD, Respiratory viral infections in patients with single ventricle congenital heart disease., Midwest Pediatric Cardiology Meeting, Virtual Meeting, 2021 |
COMMITTEE SERVICE: |
Medical College of Wisconsin |
2018 Cardiovascular Center Research Retreat Abstract Selection Committee, Medical College of Wisconsin |
2020 Grant Reviewer, Cardiovascular Center, Medical College of Wisconsin |
2020 - 2021 Grant Reviewer, Advancing a Healthier Wisconsin: Collaborative Research for Improved Health, Basic Science Review Panel, Advancing a Healthier Wisconsin |
Hospital |
2017 - Present Pediatric Resident Intern Selection Commitee, Pediatrics, Children's Wisconsin |
2018 - Present Pediatric Cardiology Fellowship Selection Committee, Pediatrics, Children's Wisconsin |
2020 Grant Reviewer, Children's Research Institute Pilot Innovation Award, Children's Research Institute, Children's Wisconsin |
BIBLIOGRAPHY |
Refereed Journal Publications/Original Papers |
1. Spearman AD, Sweet K, Zhou XP, McLennan J, Couch FJ, Toland AE. Clinically applicable models to characterize BRCA1 and BRCA2 variants of uncertain significance. J Clin Oncol. 2008 Nov 20;26(33):5393-400. PMCID: PMC2651073 |
2. Dworkin AM, Spearman AD, Tseng SY, Sweet K, Toland AE. Methylation not a frequent "second hit" in tumors with germline BRCA mutations. Fam Cancer. 2009;8(4):339-46. |
3. Spearman AD, Williams P. Supraventricular tachycardia in infancy and childhood. Pediatr Ann. 2014 Nov;43(11):456-60. |
4. Spearman AD. Epigenetics for the pediatric cardiologist. Congenit Heart Dis. 2017 Dec;12(6):828-833. |
5. Spearman AD, Loomba RS, Danduran M, Kovach J. Intrauterine growth restriction is not associated with decreased exercise capacity in adolescents with congenital heart disease. Congenit Heart Dis. 2018 May;13(3):369-376. |
6. Spearman AD, Hraska V, Goot BH. Isolated Left Innominate Artery: Diagnosis of a Rare Aortic Arch Anomaly. World J Pediatr Congenit Heart Surg. 2018 Nov;9(6):708-709. |
7. Spearman AD, Ke X, Fu Q, Lane RH, Majnik A. Adverse maternal environment leads to cardiac fibrosis in adult male mice. Birth Defects Res. 2018 Dec 01;110(20):1551-1555. |
8. Spearman AD, Kindel SJ, Woods RK, Ginde S. Arteriovenous fistula creation for hypoxia after single ventricle palliation: A single-institution experience and literature review. Congenit Heart Dis. 2019 Nov;14(6):1199-1206. |
9. Thirugnanam K, Cossette SM, Lu Q, Chowdhury SR, Harmann LM, Gupta A, Spearman AD, Sonin DL, Bordas M, Kumar SN, Pan AY, Simpson PM, Strande JL, Bishop E, Zou MH, Ramchandran R. Cardiomyocyte-Specific <i>Snrk</i> Prevents Inflammation in the Heart. J Am Heart Assoc. 2019 Nov 19;8(22):e012792. PMCID: PMC6915262 |
10. Spearman AD, Ginde S. Pulmonary arteriovenous malformations in children with palliated univentricular CHD: our limited understanding persists. Cardiol Young. 2020 Apr;30(4):597-598. |
11. Spearman AD, Gupta A, Pan AY, Gronseth EI, Thirugnanam K, Gudausky TM, Foerster SR, Ramchandran R. Hepatic Vein Blood Increases Lung Microvascular Angiogenesis and Endothelial Cell Survival-Toward an Understanding of Univentricular Circulation. Semin Thorac Cardiovasc Surg. 2020 Winter;32(4):980-987. PMCID: PMC7647938 |
12. Spearman AD, Ginde S, Goot BH, Schaal AM, Feng M, Pan AY, Frommelt MA, Frommelt PC. Echocardiographic Identification of Pulmonary Artery Flow Reversal: An Indicator of Adverse Outcomes in Single Ventricle Physiology. Pediatr Cardiol. 2020 Dec;41(8):1632-1638. |
13. Van Galder H, Schaal AM, Feng M, Pan AY, Frommelt MA, Ginde S, Spearman AD. Increases in oxygen saturation following discharge from Fontan palliation - an indicator of resolution of pulmonary arteriovenous malformations? Cardiol Young. 2021 Nov;31(11):1807-1813. |
14. Spearman AD, Gupta A, Pan AY, Gudausky TM, Foerster SR, Konduri GG, Ramchandran R. sVEGFR1 Is Enriched in Hepatic Vein Blood-Evidence for a Provisional Hepatic Factor Candidate? Front Pediatr. 2021;9:679572. PMCID: PMC8236596 |
15. Gupta A, Thirugnanam K, Thamilarasan M, Mohieldin AM, Zedan HT, Prabhudesai S, Griffin MR, Spearman AD, Pan A, Palecek SP, Yalcin HC, Nauli SM, Rarick KR, Zennadi R, Ramchandran R. Cilia proteins are biomarkers of altered flow in the vasculature. JCI Insight. 2022 Mar 22;7(6). PMCID: PMC8986075 |
16. Calley BJ, Zhang L, Pan AY, Ginde S, Kindel SJ, Spearman AD. Respiratory viral infections are prevalent but uncomplicated in single ventricle CHD. Cardiol Young. 2023 Apr;33(4):557-563. |
17. Spearman AD, Ginde S. Pulmonary Vascular Sequelae of Palliated Single Ventricle Circulation: Arteriovenous Malformations and Aortopulmonary Collaterals. J Cardiovasc Dev Dis. 2022 Sep 17;9(9). PMCID: PMC9501802 |
18. Merbach M, Ramchandran R, Spearman AD. Hepatic factor may not originate from hepatocytes. Front Cardiovasc Med. 2022;9:999315. PMCID: PMC9486074 |
19. Segar DE, Pan AY, McLennan DI, Kindel SJ, Handler SS, Ginde S, Woods RK, Goot BH, Spearman AD. Clinical Variables Associated with Pre-Fontan Aortopulmonary Collateral Burden. Pediatr Cardiol. 2023 Jan;44(1):228-236. PMCID: PMC10155213 |
20. Ghorbannia A, Spearman AD, Sawalhi S, Woods RK, Maadooliat M, LaDisa JF Jr. Consistency of the continuous flow pressure gradient despite aortic arch anomalies co-existing with coarctation. medRxiv. 2023 Oct 30. PMCID: PMC10635219 |
21. Phimister A, Bushee C, Merbach M, Challa SA, Pan AY, Spearman AD. Objective Quantification of Bilateral Bubble Contrast Echocardiography Correlates with Systemic Oxygenation in Patients with Single Ventricle Circulation. J Cardiovasc Dev Dis. 2024 Mar 01;11(3). PMCID: PMC10971280 |
22. Wan T, Rousseau H, Mattern C, Tabor M, Hodges MR, Ramchandran R, Spearman AD. Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations. bioRxiv. 2024 Apr 05. PMCID: PMC11014550 |
23. Ghorbannia A, Spearman AD, Sawalhi S, Woods RK, Maadooliat M, LaDisa JF Jr. A Novel Diastolic Doppler Index Less Affected by Aortic Arch Anomalies Co-existing with Coarctation. Pediatr Cardiol. 2024 Jul 12. |
24. Wan TC, Rousseau H, Mattern C, Tabor M, Hodges MR, Ramchandran R, Spearman AD. Glenn circulation causes early and progressive shunting in a surgical model of pulmonary arteriovenous malformations. Physiol Rep. 2024 Nov;12(22):e70123. PMCID: PMC11584281 |
25. Dibbs AK, Zhang L, Pan AY, Spearman AD. Thirty-Year Prevalence of Spontaneous Hemoptysis in Palliated Single Ventricle Circulation. J Am Heart Assoc. 2025 Jun 23:e040713. |
