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Medical College of Wisconsin

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Aoy Tomita Mitchell PhD

Professor

Institution: Medical College of Wisconsin
Department: Surgery
Division: Surgery Pediatric Cardiothoracic

Member of the Cardiovascular Research Center
Member of the Mellowes Center for Genomic Sciences and Precision Medicine

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Publications (62)

Evaluating threshold for donor fraction cell-free DNA using clinically available assay for rejection in pediatric and adult heart transplantation. (Deshpande SR, Zangwill SD, Richmond ME, Kindel SJ, Schroder JN, Gaglianello N, Bichell DP, Wigger MA, Knecht KR, Thrush PT, Mahle WT, North PE, Simpson PM, Zhang L, Dasgupta M, Tomita-Mitchell A, Mitchell ME) Pediatr Transplant 2024 May;28(3):e14708 PMID: 38553812 PMCID: PMC10987078 SCOPUS ID: 2-s2.0-85189497658 03/30/2024 6 Citations

3D-bioprinting of patient-derived cardiac tissue models for studying congenital heart disease. (Wolfe JT, He W, Kim MS, Liang HL, Shradhanjali A, Jurkiewicz H, Freudinger BP, Greene AS, LaDisa JF Jr, Tayebi L, Mitchell ME, Tomita-Mitchell A, Tefft BJ) Front Cardiovasc Med 2023;10:1162731 PMID: 37293290 PMCID: PMC10247285 SCOPUS ID: 2-s2.0-85161445064 06/09/2023 21 Citations

Altered contractility, Ca²⁺ transients, and cell morphology seen in a patient-specific iPSC-CM model of Ebstein's anomaly with left ventricular noncompaction. (Thareja SK, Anfinson M, Cavanaugh M, Kim MS, Lamberton P, Radandt J, Brown R, Liang HL, Stamm K, Afzal MZ, Strande J, Frommelt MA, Lough JW, Fitts RH, Mitchell ME, Tomita-Mitchell A) Am J Physiol Heart Circ Physiol 2023 Jul 01;325(1):H149-H162 PMID: 37204873 PMCID: PMC10312315 SCOPUS ID: 2-s2.0-85164047409 05/19/2023 3 Citations

Nuclear Cell-Free DNA Predicts Adverse Events After Pediatric Cardiothoracic Surgery. (Tanem JM, Scott JP, Hoffman GM, Niebler RA, Tomita-Mitchell A, Stamm KD, Liang HL, North PE, Bertrandt RA, Woods RK, Hraska V, Mitchell ME) Ann Thorac Surg 2023 Aug;116(2):349-356 PMID: 36332680 SCOPUS ID: 2-s2.0-85150823960 11/05/2022 5 Citations

Validation of donor fraction cell-free DNA with biopsy-proven cardiac allograft rejection in children and adults. (Richmond ME, Deshpande SR, Zangwill SD, Bichell DP, Kindel SJ, Mahle WT, Schroder JN, Wigger MA, Knecht KR, Pahl E, Gaglianello NA, Goetsch MA, Simpson P, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME) J Thorac Cardiovasc Surg 2023 Feb;165(2):460-468.e2 PMID: 35643770 PMCID: PMC9617812 SCOPUS ID: 2-s2.0-85130912386 06/02/2022 14 Citations

Significance of α-Myosin Heavy Chain (MYH6) Variants in Hypoplastic Left Heart Syndrome and Related Cardiovascular Diseases. (Anfinson M, Fitts RH, Lough JW, James JM, Simpson PM, Handler SS, Mitchell ME, Tomita-Mitchell A) J Cardiovasc Dev Dis 2022 May 03;9(5) PMID: 35621855 PMCID: PMC9147009 SCOPUS ID: 2-s2.0-85130146333 05/28/2022 34 Citations

A Systematic Review of Ebstein's Anomaly with Left Ventricular Noncompaction. (Thareja SK, Frommelt MA, Lincoln J, Lough JW, Mitchell ME, Tomita-Mitchell A) J Cardiovasc Dev Dis 2022 Apr 13;9(4) PMID: 35448091 PMCID: PMC9031964 SCOPUS ID: 2-s2.0-85129039352 04/22/2022 13 Citations

Relationship between donor fraction cell-free DNA and clinical rejection in heart transplantation. (Deshpande SR, Zangwill SD, Kindel SJ, Schroder JN, Bichell DP, Wigger MA, Richmond ME, Knecht KR, Pahl E, Gaglianello NA, Mahle WT, Stamm KD, Simpson PM, Dasgupta M, Zhang L, North PE, Tomita-Mitchell A, Mitchell ME) Pediatr Transplant 2022 Jun;26(4):e14264 PMID: 35258162 SCOPUS ID: 2-s2.0-85125904987 03/09/2022 13 Citations

Elevated nuclear and mitochondrial cell-free deoxyribonucleic acid measurements are associated with death after infant cardiac surgery. (Scott JP, Tanem JM, Tomita-Mitchell A, Hoffman GM, Niebler RA, Liang HL, Simpson PM, Stamm KD, North PE, Mitchell ME) J Thorac Cardiovasc Surg 2022 Aug;164(2):367-375 PMID: 35144816 SCOPUS ID: 2-s2.0-85120861361 02/12/2022 11 Citations

Increase in nuclear cell-free DNA is associated with major adverse events in adult and pediatric heart transplant recipients. (Zangwill SD, Deshpande SR, Simpson PM, Liang HL, Zhang L, Dasgupta M, Richmond ME, Kindel SJ, Bichell DP, Mahle WT, Wigger MA, Schroder JN, Knecht KR, Pahl E, Gaglianello NA, North PE, Tomita-Mitchell A, Mitchell ME) Clin Transplant 2022 Jan;36(1):e14509 PMID: 34649304 SCOPUS ID: 2-s2.0-85120575732 10/15/2021 5 Citations

Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. (Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP) PLoS Genet 2021 Sep;17(9):e1009809 PMID: 34547032 PMCID: PMC8454942 SCOPUS ID: 2-s2.0-85116272362 09/22/2021 1 Citation

Estimate of the contemporary live-birth prevalence of recurrent 22q11.2 deletions: a cross-sectional analysis from population-based newborn screening. (Blagojevic C, Heung T, Theriault M, Tomita-Mitchell A, Chakraborty P, Kernohan K, Bulman DE, Bassett AS) CMAJ Open 2021;9(3):E802-E809 PMID: 34404688 PMCID: PMC8373039 SCOPUS ID: 2-s2.0-85114430327 08/19/2021 140 Citations

Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease. (Audain E, Wilsdon A, Breckpot J, Izarzugaza JMG, Fitzgerald TW, Kahlert AK, Sifrim A, Wünnemann F, Perez-Riverol Y, Abdul-Khaliq H, Bak M, Bassett AS, Benson DW, Berger F, Daehnert I, Devriendt K, Dittrich S, Daubeney PE, Garg V, Hackmann K, Hoff K, Hofmann P, Dombrowsky G, Pickardt T, Bauer U, Keavney BD, Klaassen S, Kramer HH, Marshall CR, Milewicz DM, Lemaire S, Coselli JS, Mitchell ME, Tomita-Mitchell A, Prakash SK, Stamm K, Stewart AFR, Silversides CK, Siebert R, Stiller B, Rosenfeld JA, Vater I, Postma AV, Caliebe A, Brook JD, Andelfinger G, Hurles ME, Thienpont B, Larsen LA, Hitz MP) PLoS Genet 2021 Jul;17(7):e1009679 PMID: 34324492 PMCID: PMC8354477 SCOPUS ID: 2-s2.0-85111770757 07/30/2021 26 Citations

Total Cell-Free DNA Predicts Death and Infection Following Pediatric and Adult Heart Transplantation. (Scott JP, Ragalie WS, Stamm KD, Mahnke DK, Liang HL, Simpson PM, Dasgupta M, Katz R, North PE, Tomita-Mitchell A, Zangwill SD, Kindel SJ, Mitchell ME) Ann Thorac Surg 2021 Oct;112(4):1282-1289 PMID: 33039362 SCOPUS ID: 2-s2.0-85103701202 10/12/2020 15 Citations

Use of Metformin in Pulmonary Vein Stenosis after TAPVR Repair. (Kirkpatrick EC, Mitchell ME, Thilly WG, Cava J, Tomita-Mitchell A, Gostjeva EV) Glob Pediatr Health 2020;7:2333794X20958924 PMID: 33029553 PMCID: PMC7522838 SCOPUS ID: 2-s2.0-85091421115 10/09/2020 2 Citations

Contractility of Induced Pluripotent Stem Cell-Cardiomyocytes With an MYH6 Head Domain Variant Associated With Hypoplastic Left Heart Syndrome. (Kim MS, Fleres B, Lovett J, Anfinson M, Samudrala SSK, Kelly LJ, Teigen LE, Cavanaugh M, Marquez M, Geurts AM, Lough JW, Mitchell ME, Fitts RH, Tomita-Mitchell A) Front Cell Dev Biol 2020;8:440 PMID: 32656206 PMCID: PMC7324479 SCOPUS ID: 2-s2.0-85087475806 07/14/2020 41 Citations

Novel KLHL26 variant associated with a familial case of Ebstein's anomaly and left ventricular noncompaction. (Samudrala SSK, North LM, Stamm KD, Earing MG, Frommelt MA, Willes R, Tripathi S, Dsouza NR, Zimmermann MT, Mahnke DK, Liang HL, Lund M, Lin CW, Geddes GC, Mitchell ME, Tomita-Mitchell A) Mol Genet Genomic Med 2020 Apr;8(4):e1152 PMID: 31985165 PMCID: PMC7196453 SCOPUS ID: 2-s2.0-85078673520 01/28/2020 15 Citations

Donor fraction cell-free DNA and rejection in adult and pediatric heart transplantation. (Richmond ME, Zangwill SD, Kindel SJ, Deshpande SR, Schroder JN, Bichell DP, Knecht KR, Mahle WT, Wigger MA, Gaglianello NA, Pahl E, Simpson PM, Dasgupta M, North PE, Hidestrand M, Tomita-Mitchell A, Mitchell ME) J Heart Lung Transplant 2020 May;39(5):454-463 PMID: 31983667 SCOPUS ID: 2-s2.0-85078178592 01/28/2020 88 Citations

Cell-free DNA donor fraction analysis in pediatric and adult heart transplant patients by multiplexed allele-specific quantitative PCR: Validation of a rapid and highly sensitive clinical test for stratification of rejection probability. (North PE, Ziegler E, Mahnke DK, Stamm KD, Thomm A, Daft P, Goetsch M, Liang HL, Baker MA, Vepraskas A, Rosenau C, Dasgupta M, Simpson P, Mitchell ME, Tomita-Mitchell A) PLoS One 2020;15(1):e0227385 PMID: 31929557 PMCID: PMC6957190 SCOPUS ID: 2-s2.0-85077765307 01/14/2020 36 Citations

Early changes in cell-free DNA levels in newly transplanted heart transplant patients. (Zangwill SD, Kindel SJ, Ragalie WS, North PE, Pollow A, Hidestrand M, Tomita-Mitchell A, Stamm KD, Mitchell ME) Pediatr Transplant 2020 Feb;24(1):e13622 PMID: 31825144 PMCID: PMC7065377 SCOPUS ID: 2-s2.0-85076338475 12/12/2019 23 Citations

Effect of endomyocardial biopsy on levels of donor-specific cell-free DNA. (Zangwill SD, Stamm KD, Hidestrand M, Tomita-Mitchell A, Mitchell ME) J Heart Lung Transplant 2019 Oct;38(10):1118-1120 PMID: 31324442 PMCID: PMC7556715 SCOPUS ID: 2-s2.0-85072281917 07/22/2019 8 Citations

Human genotyping and an experimental model reveal NPR-C as a possible contributor to morbidity in coarctation of the aorta. (LaDisa JF Jr, Tomita-Mitchell A, Stamm K, Bazan K, Mahnke DK, Goetsch MA, Wegter BJ, Gerringer JW, Repp K, Palygin O, Zietara AP, Krolikowski MM, Eddinger TJ, Alli AA, Mitchell ME) Physiol Genomics 2019 Jun 01;51(6):177-185 PMID: 31002586 PMCID: PMC6620646 SCOPUS ID: 2-s2.0-85066457176 04/20/2019 15 Citations

GSEPD: a Bioconductor package for RNA-seq gene set enrichment and projection display. (Stamm K, Tomita-Mitchell A, Bozdag S) BMC Bioinformatics 2019 Mar 06;20(1):115 PMID: 30841846 PMCID: PMC6404334 SCOPUS ID: 2-s2.0-85062495607 03/08/2019 4 Citations

Metakaryotic cells linked to pediatric pulmonary vein stenosis. (Kirkpatrick EC, Mitchell ME, Thilly WG, Hidestrand P, Tomita-Mitchell A, Hidestrand M, Gostjeva EV) Cardiovasc Pathol 2019;39:51-53 PMID: 30660022 SCOPUS ID: 2-s2.0-85059952993 01/20/2019 6 Citations

Variance of IQ is partially dependent on deletion type among 1,427 22q11.2 deletion syndrome subjects. (Zhao Y, Guo T, Fiksinski A, Breetvelt E, McDonald-McGinn DM, Crowley TB, Diacou A, Schneider M, Eliez S, Swillen A, Breckpot J, Vermeesch J, Chow EWC, Gothelf D, Duijff S, Evers R, van Amelsvoort TA, van den Bree M, Owen M, Niarchou M, Bearden CE, Ornstein C, Pontillo M, Buzzanca A, Vicari S, Armando M, Murphy KC, Murphy C, Garcia-Minaur S, Philip N, Campbell L, Morey-Cañellas J, Raventos J, Rosell J, Heine-Suner D, Shprintzen RJ, Gur RE, Zackai E, Emanuel BS, Wang T, Kates WR, Bassett AS, Vorstman JAS, Morrow BE, International 22q11.2 Brain and Behavior Consortium) Am J Med Genet A 2018 Oct;176(10):2172-2181 PMID: 30289625 PMCID: PMC6209529 SCOPUS ID: 2-s2.0-85054522149 10/06/2018 37 Citations

Noninvasive Assay for Donor Fraction of Cell-Free DNA in Pediatric Heart Transplant Recipients. (Ragalie WS, Stamm K, Mahnke D, Liang HL, Simpson P, Katz R, Tomita-Mitchell A, Kindel SJ, Zangwill S, Mitchell ME) J Am Coll Cardiol 2018 Jun 26;71(25):2982-2983 PMID: 29929623 SCOPUS ID: 2-s2.0-85048264947 06/23/2018 28 Citations

Genome-Wide Association Study to Find Modifiers for Tetralogy of Fallot in the 22q11.2 Deletion Syndrome Identifies Variants in the GPR98 Locus on 5q14.3. (Guo T, Repetto GM, McDonald McGinn DM, Chung JH, Nomaru H, Campbell CL, Blonska A, Bassett AS, Chow EWC, Mlynarski EE, Swillen A, Vermeesch J, Devriendt K, Gothelf D, Carmel M, Michaelovsky E, Schneider M, Eliez S, Antonarakis SE, Coleman K, Tomita-Mitchell A, Mitchell ME, Digilio MC, Dallapiccola B, Marino B, Philip N, Busa T, Kushan-Wells L, Bearden CE, Piotrowicz M, Hawuła W, Roberts AE, Tassone F, Simon TJ, van Duin EDA, van Amelsvoort TA, Kates WR, Zackai E, Johnston HR, Cutler DJ, Agopian AJ, Goldmuntz E, Mitchell LE, Wang T, Emanuel BS, Morrow BE, International 22q11.2 Consortium/Brain and Behavior Consortium*) Circ Cardiovasc Genet 2017 Oct;10(5):e001690 PMID: 29025761 PMCID: PMC5647121 SCOPUS ID: 2-s2.0-85032884386 10/14/2017 22 Citations

Impact of MYH6 variants in hypoplastic left heart syndrome. (Tomita-Mitchell A, Stamm KD, Mahnke DK, Kim MS, Hidestrand PM, Liang HL, Goetsch MA, Hidestrand M, Simpson P, Pelech AN, Tweddell JS, Benson DW, Lough JW, Mitchell ME) Physiol Genomics 2016 Dec 01;48(12):912-921 PMID: 27789736 PMCID: PMC5206387 SCOPUS ID: 2-s2.0-85006309110 10/30/2016 78 Citations

Ciliopathy variant burden and developmental delay in children with hypoplastic left heart syndrome. (Geddes GC, Stamm K, Mitchell M, Mussatto KA, Tomita-Mitchell A) Genet Med 2017 Jun;19(6):711-714 PMID: 27787502 SCOPUS ID: 2-s2.0-85020225756 10/28/2016 8 Citations

Metakaryotic cancer stem cells are constitutively resistant to X-rays and chemotherapeutic agents, but sensitive to many common drugs (Gostjeva EV, Koledova VV, Bai L, Duan KC, Kamath T, Nelson M, Agnihotri P, Moshinski DJ, Ping Wu L, Zukerberg L, Chung DC, Tsai S, Evans DB, Tomita-Mitchell A, Mitchell M, Thilly WG) Issues in Toxicology 2016;2016-January(29):196-249 SCOPUS ID: 2-s2.0-84986556373 01/01/2016 4 Citations

Effect of 22q11.2 deletion on bleeding and transfusion utilization in children with congenital heart disease undergoing cardiac surgery. (Brenner MK, Clarke S, Mahnke DK, Simpson P, Bercovitz RS, Tomita-Mitchell A, Mitchell ME, Newman DK) Pediatr Res 2016 Feb;79(2):318-24 PMID: 26492284 PMCID: PMC5114022 SCOPUS ID: 2-s2.0-84982285447 10/23/2015 30 Citations

Activin-A and Bmp4 levels modulate cell type specification during CHIR-induced cardiomyogenesis. (Kim MS, Horst A, Blinka S, Stamm K, Mahnke D, Schuman J, Gundry R, Tomita-Mitchell A, Lough J) PLoS One 2015;10(2):e0118670 PMID: 25706534 PMCID: PMC4338295 SCOPUS ID: 2-s2.0-84923332744 02/24/2015 33 Citations

Use of cell-free fetal DNA in maternal plasma for noninvasive prenatal screening. (Wagner AJ, Mitchell ME, Tomita-Mitchell A) Clin Perinatol 2014 Dec;41(4):957-66 PMID: 25459783 SCOPUS ID: 2-s2.0-84910116657 12/03/2014 14 Citations

The inferred cardiogenic gene regulatory network in the mammalian heart. (Bazil JN, Stamm KD, Li X, Thiagarajan R, Nelson TJ, Tomita-Mitchell A, Beard DA) PLoS One 2014;9(6):e100842 PMID: 24971943 PMCID: PMC4074065 SCOPUS ID: 2-s2.0-84903388331 06/28/2014 11 Citations

Chromosomal Imbalances in Patients with Congenital Cardiac Defects: A Meta-analysis Reveals Novel Potential Critical Regions Involved in Heart Development. (Thorsson T, Russell WW, El-Kashlan N, Soemedi R, Levine J, Geisler SB, Ackley T, Tomita-Mitchell A, Rosenfeld JA, Töpf A, Tayeh M, Goodship J, Innis JW, Keavney B, Russell MW) Congenit Heart Dis 2015;10(3):193-208 PMID: 24720490 SCOPUS ID: 2-s2.0-84933675983 04/12/2014 27 Citations

Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. (Hidestrand M, Tomita-Mitchell A, Hidestrand PM, Oliphant A, Goetsch M, Stamm K, Liang HL, Castleberry C, Benson DW, Stendahl G, Simpson PM, Berger S, Tweddell JS, Zangwill S, Mitchell ME) J Am Coll Cardiol 2014 Apr 01;63(12):1224-1226 PMID: 24140666 PMCID: PMC4988656 SCOPUS ID: 2-s2.0-84896944581 10/22/2013 77 Citations

Use of combination chemotherapy for treatment of granulomatous and lymphocytic interstitial lung disease (GLILD) in patients with common variable immunodeficiency (CVID). (Chase NM, Verbsky JW, Hintermeyer MK, Waukau JK, Tomita-Mitchell A, Casper JT, Singh S, Shahir KS, Tisol WB, Nugent ML, Rao RN, Mackinnon AC, Goodman LR, Simpson PM, Routes JM) J Clin Immunol 2013 Jan;33(1):30-9 PMID: 22930256 PMCID: PMC3557581 SCOPUS ID: 2-s2.0-84876429921 08/30/2012 190 Citations

Human gene copy number spectra analysis in congenital heart malformations. (Tomita-Mitchell A, Mahnke DK, Struble CA, Tuffnell ME, Stamm KD, Hidestrand M, Harris SE, Goetsch MA, Simpson PM, Bick DP, Broeckel U, Pelech AN, Tweddell JS, Mitchell ME) Physiol Genomics 2012 May 01;44(9):518-41 PMID: 22318994 PMCID: PMC3426426 SCOPUS ID: 2-s2.0-84862128193 02/10/2012 93 Citations

Influence of temperature during transportation on cell-free DNA analysis. (Hidestrand M, Stokowski R, Song K, Oliphant A, Deavers J, Goetsch M, Simpson P, Kuhlman R, Ames M, Mitchell M, Tomita-Mitchell A) Fetal Diagn Ther 2012;31(2):122-8 PMID: 22261730 SCOPUS ID: 2-s2.0-84859006623 01/21/2012 71 Citations

Selective analysis of cell-free DNA in maternal blood for evaluation of fetal trisomy. (Sparks AB, Wang ET, Struble CA, Barrett W, Stokowski R, McBride C, Zahn J, Lee K, Shen N, Doshi J, Sun M, Garrison J, Sandler J, Hollemon D, Pattee P, Tomita-Mitchell A, Mitchell M, Stuelpnagel J, Song K, Oliphant A) Prenat Diagn 2012 Jan;32(1):3-9 PMID: 22223233 PMCID: PMC3500507 SCOPUS ID: 2-s2.0-84857502701 01/10/2012 241 Citations

Exploring the environmental and genetic etiologies of congenital heart defects: the Wisconsin Pediatric Cardiac Registry. (Harris SE, Cronk C, Cassidy LD, Simpson P, Tomita-Mitchell A, Pelech AN) J Registry Manag 2011;38(1):24-9 PMID: 22097702 SCOPUS ID: 2-s2.0-84856376667 11/22/2011 8 Citations

Making a definitive diagnosis: successful clinical application of whole exome sequencing in a child with intractable inflammatory bowel disease. (Worthey EA, Mayer AN, Syverson GD, Helbling D, Bonacci BB, Decker B, Serpe JM, Dasu T, Tschannen MR, Veith RL, Basehore MJ, Broeckel U, Tomita-Mitchell A, Arca MJ, Casper JT, Margolis DA, Bick DP, Hessner MJ, Routes JM, Verbsky JW, Jacob HJ, Dimmock DP) Genet Med 2011 Mar;13(3):255-62 PMID: 21173700 SCOPUS ID: 2-s2.0-79251645624 12/22/2010 629 Citations

Non-invasive prenatal detection of trisomy 21 using tandem single nucleotide polymorphisms. (Ghanta S, Mitchell ME, Ames M, Hidestrand M, Simpson P, Goetsch M, Thilly WG, Struble CA, Tomita-Mitchell A) PLoS One 2010 Oct 08;5(10):e13184 PMID: 20949031 PMCID: PMC2951898 SCOPUS ID: 2-s2.0-78149464048 10/16/2010 17 Citations

Report of the pediatric heart network and national heart, lung, and blood institute working group on the perioperative management of congenital heart disease. (Kaltman JR, Andropoulos DB, Checchia PA, Gaynor JW, Hoffman TM, Laussen PC, Ohye RG, Pearson GD, Pigula F, Tweddell J, Wernovsky G, Del Nido P, Perioperative Working Group) Circulation 2010 Jun 29;121(25):2766-72 PMID: 20585021 SCOPUS ID: 2-s2.0-77954235407 06/30/2010 75 Citations

Multiplexed quantitative real-time PCR to detect 22q11.2 deletion in patients with congenital heart disease. (Tomita-Mitchell A, Mahnke DK, Larson JM, Ghanta S, Feng Y, Simpson PM, Broeckel U, Duffy K, Tweddell JS, Grossman WJ, Routes JM, Mitchell ME) Physiol Genomics 2010 Sep;42A(1):52-60 PMID: 20551144 PMCID: PMC2957771 SCOPUS ID: 2-s2.0-77957122165 06/17/2010 39 Citations

Metakaryotic stem cell lineages in organogenesis of humans and other metazoans. (Gostjeva EV, Koledova V, Tomita-Mitchell A, Mitchell M, Goetsch MA, Varmuza S, Fomina JN, Darroudi F, Thilly WG) Organogenesis 2009 Oct;5(4):191-200 PMID: 20539738 PMCID: PMC2878747 SCOPUS ID: 2-s2.0-74549124470 06/12/2010 10 Citations

Investigation of somatic NKX2-5 mutations in congenital heart disease. (Draus JM Jr, Hauck MA, Goetsch M, Austin EH 3rd, Tomita-Mitchell A, Mitchell ME) J Med Genet 2009 Feb;46(2):115-22 PMID: 19181906 PMCID: PMC2628540 SCOPUS ID: 2-s2.0-62149117229 02/03/2009 59 Citations

GATA4 sequence variants in patients with congenital heart disease. (Tomita-Mitchell A, Maslen CL, Morris CD, Garg V, Goldmuntz E) J Med Genet 2007 Dec;44(12):779-83 PMID: 18055909 PMCID: PMC2652815 SCOPUS ID: 2-s2.0-37249090635 12/07/2007 190 Citations

The molecular basis of congenital heart disease. (Mitchell ME, Sander TL, Klinkner DB, Tomita-Mitchell A) Semin Thorac Cardiovasc Surg 2007;19(3):228-37 PMID: 17983950 SCOPUS ID: 2-s2.0-35748971489 11/07/2007 46 Citations

Spectrum of heart disease associated with murine and human GATA4 mutation. (Rajagopal SK, Ma Q, Obler D, Shen J, Manichaikul A, Tomita-Mitchell A, Boardman K, Briggs C, Garg V, Srivastava D, Goldmuntz E, Broman KW, Benson DW, Smoot LB, Pu WT) J Mol Cell Cardiol 2007 Dec;43(6):677-85 PMID: 17643447 PMCID: PMC2573470 SCOPUS ID: 2-s2.0-35048838310 07/24/2007 225 Citations

Molecular and cellular basis of congenital heart disease. (Sander TL, Klinkner DB, Tomita-Mitchell A, Mitchell ME) Pediatr Clin North Am 2006 Oct;53(5):989-1009, x PMID: 17027620 SCOPUS ID: 2-s2.0-33749431116 10/10/2006 18 Citations

Design of an automated multicapillary instrument with fraction collection for DNA mutation discovery by constant denaturant capillary electrophoresis (CDCE). (Li Q, Deka C, Glassner BJ, Arnold K, Li-Sucholeiki XC, Tomita-Mitchell A, Thilly WG, Karger BL) J Sep Sci 2005 Aug;28(12):1375-89 PMID: 16138690 SCOPUS ID: 2-s2.0-23944499103 09/06/2005 12 Citations

Scanning the beta-globin gene for mutations in large populations by denaturing capillary and gel electrophoresis. (Li-Sucholeiki XC, Hu G, Perls T, Tomita-Mitchell A, Thilly WG) Electrophoresis 2005 Jun;26(13):2531-8 PMID: 15948210 SCOPUS ID: 2-s2.0-22244480969 06/11/2005 12 Citations

Detection and frequency estimation of rare variants in pools of genomic DNA from large populations using mutational spectrometry. (Li-Sucholeiki XC, Tomita-Mitchell A, Arnold K, Glassner BJ, Thompson T, Murthy JV, Berk L, Lange C, Leong-Morgenthaler PM, MacDougall D, Munro J, Cannon D, Mistry T, Miller A, Deka C, Karger B, Gillespie KM, Ekstrøm PO, Todd JA, Thilly WG) Mutat Res 2005 Mar 01;570(2):267-80 PMID: 15708585 SCOPUS ID: 2-s2.0-13544268461 02/15/2005 15 Citations

Diversity and dynamics of a north atlantic coastal Vibrio community. (Thompson JR, Randa MA, Marcelino LA, Tomita-Mitchell A, Lim E, Polz MF) Appl Environ Microbiol 2004 Jul;70(7):4103-10 PMID: 15240289 PMCID: PMC444776 SCOPUS ID: 2-s2.0-3242798356 07/09/2004 303 Citations

The mutational spectrum of the HPRT gene from human T cells in vivo shares a significant concordant set of hot spots with MNNG-treated human cells. (Tomita-Mitchell A, Ling LL, Glover CL, Goodluck-Griffith J, Thilly WG) Cancer Res 2003 Sep 15;63(18):5793-8 PMID: 14522901 SCOPUS ID: 2-s2.0-0141731313 10/03/2003 11 Citations

Identification of in vivo mutations in exon 5 of the human HPRT gene in a set of pooled T-cell mutants by constant denaturant capillary electrophoresis (CDCE). (Fält S, Kumar R, Wennborg A, Tomita-Mitchell A, Thilly WG, Lambert B) Mutat Res 2000 Jul 20;452(1):57-66 PMID: 10894891 SCOPUS ID: 2-s2.0-0343962276 07/15/2000 1 Citation

Mismatch repair deficient human cells: spontaneous and MNNG-induced mutational spectra in the HPRT gene. (Tomita-Mitchell A, Kat AG, Marcelino LA, Li-Sucholeiki XC, Goodluck-Griffith J, Thilly WG) Mutat Res 2000 May 30;450(1-2):125-38 PMID: 10838138 SCOPUS ID: 2-s2.0-0034733020 06/06/2000 37 Citations

Population risk and physiological rate parameters for colon cancer. The union of an explicit model for carcinogenesis with the public health records of the United States. (Herrero-Jimenez P, Tomita-Mitchell A, Furth EE, Morgenthaler S, Thilly WG) Mutat Res 2000 Jan 17;447(1):73-116 PMID: 10686307 SCOPUS ID: 2-s2.0-0033984511 02/25/2000 44 Citations

Single nucleotide polymorphism spectra in newborns and centenarians: identification of genes coding for rise of mortal disease. (Tomita-Mitchell A, Muniappan BP, Herrero-Jimenez P, Zarbl H, Thilly WG) Gene 1998 Nov 26;223(1-2):381-91 PMID: 9858772 SCOPUS ID: 2-s2.0-0032570015 12/22/1998 27 Citations

Mutation, cell kinetics, and subpopulations at risk for colon cancer in the United States. (Herrero-Jimenez P, Thilly G, Southam PJ, Tomita-Mitchell A, Morgenthaler S, Furth EE, Thilly WG) Mutat Res 1998 May 25;400(1-2):553-78 PMID: 9685710 SCOPUS ID: 2-s2.0-0032565556 08/01/1998 45 Citations

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Profiles for MCW, MU, MSOE, UWM, BCW, CW, Froedtert, and VA Faculty

Aoy Tomita Mitchell PhD

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Publications (62)