Medical College of Wisconsin
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Constanza Garcia Keller PhD

Constanza Garcia Keller PhD profile photo picture

Assistant Professor

Institution: Medical College of Wisconsin
Department: Pharmacology and Toxicology
Program: Pharmacology

Research Areas of Interest

  • Extracellular Matrix
  • Focal Adhesion Kinase 1
  • Integrins
  • Matrix Metalloproteinases
  • Neuroendocrinology
  • Neuroimmunomodulation
  • Neuronal Plasticity
  • Stress Disorders, Post-Traumatic
  • Substance-Related Disorders

    • Publications (31)

  • Δ9 -Tetrahydrocannabinol self-administration induces cell type-specific adaptations in the nucleus accumbens core. (Garcia-Keller C, Hohmeister M, Seidling K, Beloate L, Chioma V, Spencer S, Kalivas P, Neuhofer D) Addict Biol 2023 Aug;28(8):e13286 PMID: 37500492 PMCID: PMC10924663 SCOPUS ID: 2-s2.0-85165505517 07/28/2023       2 Citations
  • Impairment of glutamate homeostasis in the nucleus accumbens core underpins cross-sensitization to cocaine following chronic restraint stress. (Avalos MP, Guzman AS, Garcia-Keller C, Mongi-Bragato B, Esparza MA, Rigoni D, Sanchez MA, Calfa GD, Bollati FA, Cancela LM) Front Physiol 2022;13:896268 PMID: 36091376 PMCID: PMC9462460 SCOPUS ID: 2-s2.0-85137982447 09/13/2022       1 Citation
  • Plasticity in astrocyte subpopulations regulates heroin relapse. (Kruyer A, Angelis A, Garcia-Keller C, Li H, Kalivas PW) Sci Adv 2022 Aug 12;8(32):eabo7044 PMID: 35947652 PMCID: PMC9365285 SCOPUS ID: 2-s2.0-85135951017 08/11/2022       8 Citations
  • Assessing combined effects of varenicline and N-acetylcysteine on reducing nicotine seeking in rats. (Nall RW, Beloate LN, Meyerink ME, Penaloza T, Doolittle J, Froeliger B, Kalivas PW, Garcia-Keller C) Addict Biol 2022 Mar;27(2):e13151 PMID: 35229943 PMCID: PMC10777539 SCOPUS ID: 2-s2.0-85125307551 03/02/2022       2 Citations
  • Cannabinoid use is enhanced by stress and changes conditioned stress responses. (Hodebourg R, Meyerink ME, Crow AD, Reichel CM, Kalivas PW, Garcia-Keller C) Neuropsychopharmacology 2022 Apr;47(5):1037-1045 PMID: 35145212 PMCID: PMC8938410 SCOPUS ID: 2-s2.0-85124566111 02/12/2022    
  • Minocycline prevents chronic restraint stress-induced vulnerability to developing cocaine self-administration and associated glutamatergic mechanisms: a potential role of microglia. (Avalos MP, Guzman AS, Rigoni D, Gorostiza EA, Sanchez MA, Mongi-Bragato B, Garcia-Keller C, Perassi EM, Virgolini MB, Peralta Ramos JM, Iribarren P, Calfa GD, Bollati FA, Cancela LM) Brain Behav Immun 2022 Mar;101:359-376 PMID: 35065197 SCOPUS ID: 2-s2.0-85123990012 01/23/2022       7 Citations
  • Myelin-associated glycoprotein activation triggers glutamate uptake by oligodendrocytes in vitro and contributes to ameliorate glutamate-mediated toxicity in vivo. (Vivinetto AL, Castañares C, Garcia-Keller C, Moyano AL, Falcon C, Palandri A, Rozés-Salvador V, Rojas JI, Patrucco L, Monferran C, Cancela L, Cristiano E, Schnaar RL, Lopez PHH) Biochim Biophys Acta Mol Basis Dis 2022 Apr 01;1868(4):166324 PMID: 34954343 SCOPUS ID: 2-s2.0-85123167664 12/27/2021       1 Citation
  • Adolescent exposure to delta-9-tetrahydrocannabinol and ethanol heightens sensitivity to fear stimuli. (Smiley CE, Saleh HK, Nimchuk KE, Garcia-Keller C, Gass JT) Behav Brain Res 2021 Oct 11;415:113517 PMID: 34389427 PMCID: PMC8404161 SCOPUS ID: 2-s2.0-85112359087 08/15/2021       7 Citations
  • Behavioral and accumbens synaptic plasticity induced by cues associated with restraint stress. (Garcia-Keller C, Carter JS, Kruyer A, Kearns AM, Hopkins JL, Hodebourg R, Kalivas PW, Reichel CM) Neuropsychopharmacology 2021 Sep;46(10):1848-1856 PMID: 34226657 PMCID: PMC8357931 SCOPUS ID: 2-s2.0-85109926164 07/07/2021       17 Citations
  • Stress-induced vulnerability to develop cocaine addiction depends on cofilin modulation. (Rigoni D, Avalos MP, Boezio MJ, Guzmán AS, Calfa GD, Perassi EM, Pierotti SM, Bisbal M, Garcia-Keller C, Cancela LM, Bollati F) Neurobiol Stress 2021 Nov;15:100349 PMID: 34169122 PMCID: PMC8209265 SCOPUS ID: 2-s2.0-85108725244 06/26/2021       3 Citations
  • Endogenous enkephalin is necessary for cocaine-induced alteration in glutamate transmission within the nucleus accumbens. (Mongi-Bragato B, Avalos MP, Guzmán AS, García-Keller C, Bollati FA, Cancela LM) Eur J Neurosci 2021 Mar;53(5):1441-1449 PMID: 33159343 SCOPUS ID: 2-s2.0-85096715496 11/08/2020       3 Citations
  • Relapse-Associated Transient Synaptic Potentiation Requires Integrin-Mediated Activation of Focal Adhesion Kinase and Cofilin in D1-Expressing Neurons. (Garcia-Keller C, Scofield MD, Neuhofer D, Varanasi S, Reeves MT, Hughes B, Anderson E, Richie CT, Mejias-Aponte C, Pickel J, Hope BT, Harvey BK, Cowan CW, Kalivas PW) J Neurosci 2020 Oct 28;40(44):8463-8477 PMID: 33051346 PMCID: PMC7605418 SCOPUS ID: 2-s2.0-85094896160 10/15/2020       12 Citations
  • Long-term impact of acute restraint stress on heroin self-administration, reinstatement, and stress reactivity. (Carter JS, Kearns AM, Vollmer KM, Garcia-Keller C, Weber RA, Baker NL, Kalivas PW, Reichel CM) Psychopharmacology (Berl) 2020 Jun;237(6):1709-1721 PMID: 32125483 PMCID: PMC7857092 SCOPUS ID: 2-s2.0-85081605223 03/04/2020       14 Citations
  • Dynamic CRMP2 Regulation of CaV2.2 in the Prefrontal Cortex Contributes to the Reinstatement of Cocaine Seeking. (Buchta WC, Moutal A, Hines B, Garcia-Keller C, Smith ACW, Kalivas P, Khanna R, Riegel AC) Mol Neurobiol 2020 Jan;57(1):346-357 PMID: 31359322 PMCID: PMC6980501 SCOPUS ID: 2-s2.0-85069973712 07/31/2019       8 Citations
  • Accumbens neuroimmune signaling and dysregulation of astrocytic glutamate transport underlie conditioned nicotine-seeking behavior. (Namba MD, Kupchik YM, Spencer SM, Garcia-Keller C, Goenaga JG, Powell GL, Vicino IA, Hogue IB, Gipson CD) Addict Biol 2020 Sep;25(5):e12797 PMID: 31330570 PMCID: PMC7323912 SCOPUS ID: 2-s2.0-85069713764 07/23/2019       34 Citations
  • N-Acetylcysteine treatment during acute stress prevents stress-induced augmentation of addictive drug use and relapse. (Garcia-Keller C, Smiley C, Monforton C, Melton S, Kalivas PW, Gass J) Addict Biol 2020 Sep;25(5):e12798 PMID: 31282090 PMCID: PMC7439767 SCOPUS ID: 2-s2.0-85068669997 07/10/2019       29 Citations
  • Extracellular Matrix Signaling Through β3 Integrin Mediates Cocaine Cue-Induced Transient Synaptic Plasticity and Relapse. (Garcia-Keller C, Neuhofer D, Bobadilla AC, Spencer S, Chioma VC, Monforton C, Kalivas PW) Biol Psychiatry 2019 Sep 01;86(5):377-387 PMID: 31126696 PMCID: PMC6697624 SCOPUS ID: 2-s2.0-85065825713 05/28/2019       27 Citations
  • Effects of Methamphetamine Self-Administration and Extinction on Astrocyte Structure and Function in the Nucleus Accumbens Core. (Siemsen BM, Reichel CM, Leong KC, Garcia-Keller C, Gipson CD, Spencer S, McFaddin JA, Hooker KN, Kalivas PW, Scofield MD) Neuroscience 2019 May 15;406:528-541 PMID: 30926546 PMCID: PMC6545487 SCOPUS ID: 2-s2.0-85063947998 03/31/2019       51 Citations
  • Ventral Pallidum Is the Primary Target for Accumbens D1 Projections Driving Cocaine Seeking. (Pardo-Garcia TR, Garcia-Keller C, Penaloza T, Richie CT, Pickel J, Hope BT, Harvey BK, Kalivas PW, Heinsbroek JA) J Neurosci 2019 Mar 13;39(11):2041-2051 PMID: 30622165 PMCID: PMC6507080 SCOPUS ID: 2-s2.0-85062892740 01/10/2019       67 Citations
  • Accumbens brain-derived neurotrophic factor (BDNF) transmission inhibits cocaine seeking. (Bobadilla AC, Garcia-Keller C, Chareunsouk V, Hyde J, Medina Camacho D, Heinsbroek JA, Kalivas PW) Addict Biol 2019 Sep;24(5):860-873 PMID: 29890020 PMCID: PMC8320750 SCOPUS ID: 2-s2.0-85069485559 06/12/2018       14 Citations
  • A Model of Δ9-Tetrahydrocannabinol Self-administration and Reinstatement That Alters Synaptic Plasticity in Nucleus Accumbens. (Spencer S, Neuhofer D, Chioma VC, Garcia-Keller C, Schwartz DJ, Allen N, Scofield MD, Ortiz-Ithier T, Kalivas PW) Biol Psychiatry 2018 Oct 15;84(8):601-610 PMID: 29861097 PMCID: PMC6162175 SCOPUS ID: 2-s2.0-85047723072 06/05/2018       58 Citations
  • Accumbens Mechanisms for Cued Sucrose Seeking. (Bobadilla AC, Garcia-Keller C, Heinsbroek JA, Scofield MD, Chareunsouk V, Monforton C, Kalivas PW) Neuropsychopharmacology 2017 Nov;42(12):2377-2386 PMID: 28726801 PMCID: PMC5645741 SCOPUS ID: 2-s2.0-85031289432 07/21/2017       18 Citations
  • Accumbens nNOS Interneurons Regulate Cocaine Relapse. (Smith ACW, Scofield MD, Heinsbroek JA, Gipson CD, Neuhofer D, Roberts-Wolfe DJ, Spencer S, Garcia-Keller C, Stankeviciute NM, Smith RJ, Allen NP, Lorang MR, Griffin WC 3rd, Boger HA, Kalivas PW) J Neurosci 2017 Jan 25;37(4):742-756 PMID: 28123012 PMCID: PMC5296777 SCOPUS ID: 2-s2.0-85010904407 01/27/2017       72 Citations
  • Cocaine Use Reverses Striatal Plasticity Produced During Cocaine Seeking. (Spencer S, Garcia-Keller C, Roberts-Wolfe D, Heinsbroek JA, Mulvaney M, Sorrell A, Kalivas PW) Biol Psychiatry 2017 Apr 01;81(7):616-624 PMID: 27837917 PMCID: PMC5346331 SCOPUS ID: 2-s2.0-85014531245 11/14/2016       27 Citations
  • Addiction-like Synaptic Impairments in Diet-Induced Obesity. (Brown RM, Kupchik YM, Spencer S, Garcia-Keller C, Spanswick DC, Lawrence AJ, Simonds SE, Schwartz DJ, Jordan KA, Jhou TC, Kalivas PW) Biol Psychiatry 2017 May 01;81(9):797-806 PMID: 26826876 PMCID: PMC4889544 SCOPUS ID: 2-s2.0-84955572072 02/02/2016       69 Citations
  • Glutamatergic mechanisms of comorbidity between acute stress and cocaine self-administration. (Garcia-Keller C, Kupchik YM, Gipson CD, Brown RM, Spencer S, Bollati F, Esparza MA, Roberts-Wolfe DJ, Heinsbroek JA, Bobadilla AC, Cancela LM, Kalivas PW) Mol Psychiatry 2016 Aug;21(8):1063-9 PMID: 26821978 PMCID: PMC4823171 SCOPUS ID: 2-s2.0-84979220561 01/30/2016       27 Citations
  • Enkephalin is essential for the molecular and behavioral expression of cocaine sensitization. (Mongi-Bragato B, Zamponi E, García-Keller C, Assis MA, Virgolini MB, Mascó DH, Zimmer A, Cancela LM) Addict Biol 2016 Mar;21(2):326-38 PMID: 25431310 SCOPUS ID: 2-s2.0-84959333935 11/29/2014       15 Citations
  • Cross-sensitization between cocaine and acute restraint stress is associated with sensitized dopamine but not glutamate release in the nucleus accumbens. (Garcia-Keller C, Martinez SA, Esparza MA, Bollati F, Kalivas PW, Cancela LM) Eur J Neurosci 2013 Mar;37(6):982-95 PMID: 23360446 PMCID: PMC4356180 SCOPUS ID: 2-s2.0-84875366554 01/31/2013       38 Citations
  • Toll-like receptor 2 ligands promote microglial cell death by inducing autophagy. (Arroyo DS, Soria JA, Gaviglio EA, Garcia-Keller C, Cancela LM, Rodriguez-Galan MC, Wang JM, Iribarren P) FASEB J 2013 Jan;27(1):299-312 PMID: 23073832 PMCID: PMC3528320 SCOPUS ID: 2-s2.0-84871910198 10/18/2012       42 Citations
  • Stress-induced sensitization to cocaine: actin cytoskeleton remodeling within mesocorticolimbic nuclei. (Esparza MA, Bollati F, Garcia-Keller C, Virgolini MB, Lopez LM, Brusco A, Shen HW, Kalivas PW, Cancela LM) Eur J Neurosci 2012 Oct;36(8):3103-17 PMID: 22882295 PMCID: PMC4346257 SCOPUS ID: 2-s2.0-84867555380 08/14/2012       25 Citations
  • Decrease of lymphoproliferative response by amphetamine is mediated by dopamine from the nucleus accumbens: influence on splenic met-enkephalin levels. (Assis MA, Valdomero A, García-Keller C, Sotomayor C, Cancela LM) Brain Behav Immun 2011 May;25(4):647-57 PMID: 21237264 SCOPUS ID: 2-s2.0-79954812196 01/18/2011       11 Citations
    • Last update: 07/28/2023