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Jieqing Zhu PhD
Assistant Professor, Associate Investigator
Institution:
BloodCenter of Wisconsin
Department:
Biochemistry
Member of the
Cancer Center
Member of the
Cardiovascular Center
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Publications (37)
High-resolution mapping of the polyclonal immune response to the human platelet alloantigen HPA-1a (Pl
A1
).
(Zhi H, Ahlen MT, Thinn AMM, Weiler H, Curtis BR, Skogen B, Zhu J, Newman PJ)
Blood Adv
2018 Nov 13;2(21):3001-3011 PMID: 30413435 PMCID: PMC6234362 SCOPUS ID: 2-s2.0-85067320916 11/11/2018
19 Citations
Autonomous conformational regulation of β
3
integrin and the conformation-dependent property of HPA-1a alloantibodies.
(Thinn AMM, Wang Z, Zhou D, Zhao Y, Curtis BR, Zhu J)
Proc Natl Acad Sci U S A
2018 Sep 25;115(39):E9105-E9114 PMID: 30209215 PMCID: PMC6166792 SCOPUS ID: 2-s2.0-85054028338 09/14/2018
20 Citations
Structure of an extended β
3
integrin.
(Zhou D, Thinn AMM, Zhao Y, Wang Z, Zhu J)
Blood
2018 Aug 30;132(9):962-972 PMID: 30018079 PMCID: PMC6117741 SCOPUS ID: 2-s2.0-85052783183 07/19/2018
14 Citations
The membrane-distal regions of integrin α cytoplasmic domains contribute differently to integrin inside-out activation.
(Thinn AMM, Wang Z, Zhu J)
Sci Rep
2018 Mar 22;8(1):5067 PMID: 29568062 PMCID: PMC5864728 SCOPUS ID: 2-s2.0-85044319699 03/24/2018
8 Citations
Csk/CD148 and platelet SFK activation: a balancing act!
(Zhu J)
Blood
2018 Mar 08;131(10):1042-1043 PMID: 29519930 PMCID: PMC5863704 SCOPUS ID: 2-s2.0-85047742099 03/10/2018
3 Citations
A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding.
(Wang Z, Thinn AMM, Zhu J)
J Biol Chem
2017 Dec 15;292(50):20756-20768 PMID: 29079572 PMCID: PMC5733610 SCOPUS ID: 2-s2.0-85038357154 10/29/2017
9 Citations
Low-affinity binding in
cis
to P2Y
2
R mediates force-dependent integrin activation during hantavirus infection.
(Bondu V, Wu C, Cao W, Simons PC, Gillette J, Zhu J, Erb L, Zhang XF, Buranda T)
Mol Biol Cell
2017 Oct 15;28(21):2887-2903 PMID: 28835374 PMCID: PMC5638590 SCOPUS ID: 2-s2.0-85031296470 08/25/2017
12 Citations
The importance of N-glycosylation on β
3
integrin ligand binding and conformational regulation.
(Cai X, Thinn AMM, Wang Z, Shan H, Zhu J)
Sci Rep
2017 Jul 05;7(1):4656 PMID: 28680094 PMCID: PMC5498496 SCOPUS ID: 2-s2.0-85021948659 07/07/2017
46 Citations
The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function.
(Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ)
J Biol Chem
2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 SCOPUS ID: 2-s2.0-85002858868 10/30/2016
26 Citations
Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia.
(Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ)
Arterioscler Thromb Vasc Biol
2016 Aug;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 SCOPUS ID: 2-s2.0-84973532000 06/11/2016
76 Citations
Structural basis for PECAM-1 homophilic binding.
(Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J)
Blood
2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 SCOPUS ID: 2-s2.0-84960356253 12/25/2015
42 Citations
Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase.
(Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ)
PLoS One
2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 SCOPUS ID: 2-s2.0-84942901879 08/21/2015
28 Citations
Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3.
(Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA)
Blood
2015 Oct 29;126(18):2138-45 PMID: 26282540 PMCID: PMC4626254 SCOPUS ID: 2-s2.0-84945906414 08/19/2015
24 Citations
The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation.
(Liu J, Wang Z, Thinn AM, Ma YQ, Zhu J)
J Cell Sci
2015 May 01;128(9):1718-31 PMID: 25749862 PMCID: PMC6518327 SCOPUS ID: 2-s2.0-84929492742 03/10/2015
19 Citations
Modulation of integrin activation and signaling by α1/α1'-helix unbending at the junction.
(Zhang C, Liu J, Jiang X, Haydar N, Zhang C, Shan H, Zhu J)
J Cell Sci
2013 Dec 15;126(Pt 24):5735-47 PMID: 24144695 SCOPUS ID: 2-s2.0-84890487402 10/23/2013
24 Citations
Complete integrin headpiece opening in eight steps.
(Zhu J, Zhu J, Springer TA)
J Cell Biol
2013 Jun 24;201(7):1053-68 PMID: 23798730 PMCID: PMC3691460 SCOPUS ID: 2-s2.0-84880008208 06/27/2013
174 Citations
Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin.
(Bougie DW, Rasmussen M, Zhu J, Aster RH)
Blood
2012 Jun 28;119(26):6317-25 PMID: 22490676 PMCID: PMC3383197 SCOPUS ID: 2-s2.0-84863510984 04/12/2012
33 Citations
Sequence and structure relationships within von Willebrand factor.
(Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA)
Blood
2012 Jul 12;120(2):449-58 PMID: 22490677 PMCID: PMC3398765 SCOPUS ID: 2-s2.0-84864055963 04/12/2012
223 Citations
Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS.
(Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS)
Sci Transl Med
2012 Mar 14;4(125):125ra32 PMID: 22422993 PMCID: PMC3390238 SCOPUS ID: 2-s2.0-84863375270 03/17/2012
68 Citations
Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling.
(Wang W, Zhu J, Springer TA, Luo BH)
J Biol Chem
2011 Jan 21;286(3):1860-7 PMID: 21081497 PMCID: PMC3023481 SCOPUS ID: 2-s2.0-78751526817 11/18/2010
15 Citations
Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor.
(Lu C, Mi LZ, Grey MJ, Zhu J, Graef E, Yokoyama S, Springer TA)
Mol Cell Biol
2010 Nov;30(22):5432-43 PMID: 20837704 PMCID: PMC2976375 SCOPUS ID: 2-s2.0-78649548465 09/15/2010
163 Citations
Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening.
(Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA)
Blood
2010 Dec 02;116(23):5050-9 PMID: 20679525 PMCID: PMC3012599 SCOPUS ID: 2-s2.0-78649747986 08/04/2010
96 Citations
The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3.
(Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA)
Mol Cell
2009 Apr 24;34(2):234-49 PMID: 19394300 PMCID: PMC2694939 SCOPUS ID: 2-s2.0-64749101260 04/28/2009
126 Citations
Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling.
(Zhu J, Carman CV, Kim M, Shimaoka M, Springer TA, Luo BH)
Blood
2007 Oct 01;110(7):2475-83 PMID: 17615290 PMCID: PMC1988953 SCOPUS ID: 2-s2.0-34948882323 07/07/2007
103 Citations
Tests of the extension and deadbolt models of integrin activation.
(Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA)
J Biol Chem
2007 Apr 20;282(16):11914-20 PMID: 17301049 PMCID: PMC1952534 SCOPUS ID: 2-s2.0-34249685565 02/16/2007
50 Citations
Structural characterization of mumps virus fusion protein core.
(Liu Y, Xu Y, Lou Z, Zhu J, Hu X, Gao GF, Qiu B, Rao Z, Tien P)
Biochem Biophys Res Commun
2006 Sep 29;348(3):916-22 PMID: 16904649 PMCID: PMC7092830 SCOPUS ID: 2-s2.0-33747191789 08/15/2006
11 Citations
Crystallization and preliminary X-ray diffraction analysis of central structure domains from mumps virus F protein.
(Liu Y, Xu Y, Zhu J, Qiu B, Rao Z, Gao GF, Tien P)
Acta Crystallogr Sect F Struct Biol Cryst Commun
2005 Sep 01;61(Pt 9):855-7 PMID: 16511178 PMCID: PMC1978114 SCOPUS ID: 2-s2.0-33747050666 03/03/2006
4 Citations
Design and characterization of human respiratory syncytial virus entry inhibitors.
(Ni L, Zhao L, Qian Y, Zhu J, Jin Z, Chen YW, Tien P, Gao GF)
Antivir Ther
2005;10(7):833-40 PMID: 16312179 SCOPUS ID: 2-s2.0-27844511949 11/30/2005
15 Citations
Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion.
(Zhu J, Jiang X, Liu Y, Tien P, Gao GF)
J Mol Biol
2005 Dec 02;354(3):601-13 PMID: 16253271 PMCID: PMC7094301 SCOPUS ID: 2-s2.0-27744533984 10/29/2005
13 Citations
Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain.
(Ni L, Zhu J, Zhang J, Yan M, Gao GF, Tien P)
Biochem Biophys Res Commun
2005 Apr 29;330(1):39-45 PMID: 15781229 PMCID: PMC7092889 SCOPUS ID: 2-s2.0-15444363201 03/23/2005
28 Citations
Characterization of BIV Env core: implication for mechanism of BIV-mediated cell fusion.
(Li S, Zhu J, Peng Y, Cui S, Wang C, Gao GF, Tien P)
Biochem Biophys Res Commun
2005 Apr 08;329(2):603-9 PMID: 15737628 PMCID: PMC7117376 SCOPUS ID: 2-s2.0-14644390292 03/02/2005
3 Citations
Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus.
(Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z)
Biochemistry
2004 Nov 09;43(44):14064-71 PMID: 15518555 SCOPUS ID: 2-s2.0-8344260757 11/03/2004
53 Citations
Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors.
(Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF)
Biochem Biophys Res Commun
2004 Jun 18;319(1):283-8 PMID: 15158473 PMCID: PMC7111185 SCOPUS ID: 2-s2.0-2442705099 05/26/2004
94 Citations
Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein.
(Liu Y, Zhu J, Feng MG, Tien P, Gao GF)
Arch Biochem Biophys
2004 Jan 01;421(1):143-8 PMID: 14678795 SCOPUS ID: 2-s2.0-0346848907 12/18/2003
21 Citations
Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein.
(Zhu J, Li P, Wu T, Gao F, Ding Y, Zhang CW, Rao Z, Gao GF, Tien P)
Protein Eng
2003 May;16(5):373-9 PMID: 12826729 SCOPUS ID: 2-s2.0-0038111976 06/27/2003
19 Citations
Crystallization and preliminary X-ray crystallographic analysis of the trimer core from measles virus fusion protein.
(Zhu J, Ding Y, Gao F, Wu T, Zhang CW, Tien P, Rao Z, Gao GF)
Acta Crystallogr D Biol Crystallogr
2003 Mar;59(Pt 3):587-90 PMID: 12595734 SCOPUS ID: 2-s2.0-0037350119 02/22/2003
11 Citations
The fusion protein core of measles virus forms stable coiled-coil trimer.
(Zhu J, Zhang CW, Qi Y, Tien P, Gao GF)
Biochem Biophys Res Commun
2002 Dec 20;299(5):897-902 PMID: 12470664 SCOPUS ID: 2-s2.0-0036926562 12/10/2002
26 Citations
Last update: 03/15/2022