Medical College of Wisconsin
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Jieqing Zhu PhD

Jieqing Zhu PhD

Assistant Professor, Associate Investigator

Institution: BloodCenter of Wisconsin
Department: Biochemistry

Member of the Cancer Center
Member of the Cardiovascular Center


  • Csk/CD148 and platelet SFK activation: a balancing act! (Zhu J) Blood 2018 Mar 08;131(10):1042-1043 PMID: 29519930 PMCID: PMC5863704 03/10/2018
  • A pivotal role for a conserved bulky residue at the α1-helix of the αI integrin domain in ligand binding. (Wang Z, Thinn AMM, Zhu J) J Biol Chem 2017 Dec 15;292(50):20756-20768 PMID: 29079572 PMCID: PMC5733610 10/29/2017
  • Low-affinity binding in to P2YR mediates force-dependent integrin activation during hantavirus infection. (Bondu V, Wu C, Cao W, Simons PC, Gillette J, Zhu J, Erb L, Zhang XF, Buranda T) Mol Biol Cell 2017 Oct 15;28(21):2887-2903 PMID: 28835374 PMCID: PMC5638590 08/25/2017
  • The importance of N-glycosylation on β integrin ligand binding and conformational regulation. (Cai X, Thinn AMM, Wang Z, Shan H, Zhu J) Sci Rep 2017 Jul 05;7(1):4656 PMID: 28680094 PMCID: PMC5498496 07/07/2017
  • The Role of Sialylated Glycans in Human Platelet Endothelial Cell Adhesion Molecule 1 (PECAM-1)-mediated Trans Homophilic Interactions and Endothelial Cell Barrier Function. (Lertkiatmongkol P, Paddock C, Newman DK, Zhu J, Thomas MJ, Newman PJ) J Biol Chem 2016 Dec 09;291(50):26216-26225 PMID: 27793989 PMCID: PMC5207088 10/30/2016
  • Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia. (Santoso S, Wihadmadyatami H, Bakchoul T, Werth S, Al-Fakhri N, Bein G, Kiefel V, Zhu J, Newman PJ, Bayat B, Sachs UJ) Arterioscler Thromb Vasc Biol 2016 08;36(8):1517-24 PMID: 27283740 PMCID: PMC5140275 06/11/2016
  • Structural basis for PECAM-1 homophilic binding. (Paddock C, Zhou D, Lertkiatmongkol P, Newman PJ, Zhu J) Blood 2016 Feb 25;127(8):1052-61 PMID: 26702061 PMCID: PMC4768429 12/25/2015
  • Platelet Activation and Thrombus Formation over IgG Immune Complexes Requires Integrin αIIbβ3 and Lyn Kinase. (Zhi H, Dai J, Liu J, Zhu J, Newman DK, Gao C, Newman PJ) PLoS One 2015;10(8):e0135738 PMID: 26291522 PMCID: PMC4546160 08/21/2015
  • Structural basis for quinine-dependent antibody binding to platelet integrin αIIbβ3. (Zhu J, Zhu J, Bougie DW, Aster RH, Springer TA) Blood 2015 Oct 29;126(18):2138-45 PMID: 26282540 PMCID: PMC4626254 08/19/2015
  • The dual structural roles of the membrane distal region of the α-integrin cytoplasmic tail during integrin inside-out activation. (Liu J, Wang Z, Thinn AM, Ma YQ, Zhu J) J Cell Sci 2015 May 01;128(9):1718-31 PMID: 25749862 03/10/2015
  • Modulation of integrin activation and signaling by α1/α1'-helix unbending at the junction. (Zhang C, Liu J, Jiang X, Haydar N, Zhang C, Shan H, Zhu J) J Cell Sci 2013 Dec 15;126(Pt 24):5735-47 PMID: 24144695 10/23/2013
  • Complete integrin headpiece opening in eight steps. (Zhu J, Zhu J, Springer TA) J Cell Biol 2013 Jun 24;201(7):1053-68 PMID: 23798730 PMCID: PMC3691460 06/27/2013
  • Antibodies causing thrombocytopenia in patients treated with RGD-mimetic platelet inhibitors recognize ligand-specific conformers of αIIb/β3 integrin. (Bougie DW, Rasmussen M, Zhu J, Aster RH) Blood 2012 Jun 28;119(26):6317-25 PMID: 22490676 PMCID: PMC3383197 04/12/2012
  • Sequence and structure relationships within von Willebrand factor. (Zhou YF, Eng ET, Zhu J, Lu C, Walz T, Springer TA) Blood 2012 Jul 12;120(2):449-58 PMID: 22490677 PMCID: PMC3398765 04/12/2012
  • Structure-guided design of a high-affinity platelet integrin αIIbβ3 receptor antagonist that disrupts Mg²⁺ binding to the MIDAS. (Zhu J, Choi WS, McCoy JG, Negri A, Zhu J, Naini S, Li J, Shen M, Huang W, Bougie D, Rasmussen M, Aster R, Thomas CJ, Filizola M, Springer TA, Coller BS) Sci Transl Med 2012 Mar 14;4(125):125ra32 PMID: 22422993 PMCID: PMC3390238 03/17/2012
  • Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signaling. (Wang W, Zhu J, Springer TA, Luo BH) J Biol Chem 2011 Jan 21;286(3):1860-7 PMID: 21081497 PMCID: PMC3023481 11/18/2010
  • Structural evidence for loose linkage between ligand binding and kinase activation in the epidermal growth factor receptor. (Lu C, Mi LZ, Grey MJ, Zhu J, Graef E, Yokoyama S, Springer TA) Mol Cell Biol 2010 Nov;30(22):5432-43 PMID: 20837704 PMCID: PMC2976375 09/15/2010
  • Closed headpiece of integrin αIIbβ3 and its complex with an αIIbβ3-specific antagonist that does not induce opening. (Zhu J, Zhu J, Negri A, Provasi D, Filizola M, Coller BS, Springer TA) Blood 2010 Dec 02;116(23):5050-9 PMID: 20679525 PMCID: PMC3012599 08/04/2010
  • The structure of a receptor with two associating transmembrane domains on the cell surface: integrin alphaIIbbeta3. (Zhu J, Luo BH, Barth P, Schonbrun J, Baker D, Springer TA) Mol Cell 2009 Apr 24;34(2):234-49 PMID: 19394300 PMCID: PMC2694939 04/28/2009
  • Requirement of alpha and beta subunit transmembrane helix separation for integrin outside-in signaling. (Zhu J, Carman CV, Kim M, Shimaoka M, Springer TA, Luo BH) Blood 2007 Oct 01;110(7):2475-83 PMID: 17615290 PMCID: PMC1988953 07/07/2007
  • Tests of the extension and deadbolt models of integrin activation. (Zhu J, Boylan B, Luo BH, Newman PJ, Springer TA) J Biol Chem 2007 Apr 20;282(16):11914-20 PMID: 17301049 PMCID: PMC1952534 02/16/2007
  • Structural characterization of mumps virus fusion protein core. (Liu Y, Xu Y, Lou Z, Zhu J, Hu X, Gao GF, Qiu B, Rao Z, Tien P) Biochem Biophys Res Commun 2006 Sep 29;348(3):916-22 PMID: 16904649 08/15/2006
  • Crystallization and preliminary X-ray diffraction analysis of central structure domains from mumps virus F protein. (Liu Y, Xu Y, Zhu J, Qiu B, Rao Z, Gao GF, Tien P) Acta Crystallogr Sect F Struct Biol Cryst Commun 2005 Sep 01;61(Pt 9):855-7 PMID: 16511178 PMCID: PMC1978114 03/03/2006
  • Design and characterization of human respiratory syncytial virus entry inhibitors. (Ni L, Zhao L, Qian Y, Zhu J, Jin Z, Chen YW, Tien P, Gao GF) Antivir Ther 2005;10(7):833-40 PMID: 16312179 11/30/2005
  • Design and characterization of viral polypeptide inhibitors targeting Newcastle disease virus fusion. (Zhu J, Jiang X, Liu Y, Tien P, Gao GF) J Mol Biol 2005 Dec 02;354(3):601-13 PMID: 16253271 10/29/2005
  • Design of recombinant protein-based SARS-CoV entry inhibitors targeting the heptad-repeat regions of the spike protein S2 domain. (Ni L, Zhu J, Zhang J, Yan M, Gao GF, Tien P) Biochem Biophys Res Commun 2005 Apr 29;330(1):39-45 PMID: 15781229 03/23/2005
  • Characterization of BIV Env core: implication for mechanism of BIV-mediated cell fusion. (Li S, Zhu J, Peng Y, Cui S, Wang C, Gao GF, Tien P) Biochem Biophys Res Commun 2005 Apr 08;329(2):603-9 PMID: 15737628 03/02/2005
  • Characterization of the heptad repeat regions, HR1 and HR2, and design of a fusion core structure model of the spike protein from severe acute respiratory syndrome (SARS) coronavirus. (Xu Y, Zhu J, Liu Y, Lou Z, Yuan F, Liu Y, Cole DK, Ni L, Su N, Qin L, Li X, Bai Z, Bell JI, Pang H, Tien P, Gao GF, Rao Z) Biochemistry 2004 Nov 09;43(44):14064-71 PMID: 15518555 11/03/2004
  • Following the rule: formation of the 6-helix bundle of the fusion core from severe acute respiratory syndrome coronavirus spike protein and identification of potent peptide inhibitors. (Zhu J, Xiao G, Xu Y, Yuan F, Zheng C, Liu Y, Yan H, Cole DK, Bell JI, Rao Z, Tien P, Gao GF) Biochem Biophys Res Commun 2004 Jun 18;319(1):283-8 PMID: 15158473 05/26/2004
  • Six-helix bundle assembly and analysis of the central core of mumps virus fusion protein. (Liu Y, Zhu J, Feng MG, Tien P, Gao GF) Arch Biochem Biophys 2004 Jan 01;421(1):143-8 PMID: 14678795 12/18/2003
  • Design and analysis of post-fusion 6-helix bundle of heptad repeat regions from Newcastle disease virus F protein. (Zhu J, Li P, Wu T, Gao F, Ding Y, Zhang CW, Rao Z, Gao GF, Tien P) Protein Eng 2003 May;16(5):373-9 PMID: 12826729 06/27/2003
  • Crystallization and preliminary X-ray crystallographic analysis of the trimer core from measles virus fusion protein. (Zhu J, Ding Y, Gao F, Wu T, Zhang CW, Tien P, Rao Z, Gao GF) Acta Crystallogr D Biol Crystallogr 2003 Mar;59(Pt 3):587-90 PMID: 12595734 02/22/2003
  • The fusion protein core of measles virus forms stable coiled-coil trimer. (Zhu J, Zhang CW, Qi Y, Tien P, Gao GF) Biochem Biophys Res Commun 2002 Dec 20;299(5):897-902 PMID: 12470664 12/10/2002
  • Last update: 09/15/2017
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