Medical College of Wisconsin
CTSICores SearchResearch InformaticsREDCap

Matt Durand PhD

Matt Durand PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Physical Medicine and Rehabilitation
Program: Adult

Member of the Cardiovascular Center


Research Experience

  • Angiotensin II
  • Endothelium-Dependent Relaxing Factors
  • Exercise
  • Exercise Therapy
  • Hypertension
  • Mitochondria
  • Nitric Oxide
  • Stroke
  • Vasodilation
  • MCW Program / Core Facilities

  • Cardiovascular Center
  • Publications

  • PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure. (Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD) Hypertension 2017 07;70(1):166-173 PMID: 28533333 PMCID: PMC5485836 05/24/2017       12 Citations
  • Regenerative Angiogenesis: Quality Over Quantity. (Durand MJ, Ait-Aissa K, Gutterman DD) Circ Res 2017 Apr 28;120(9):1379-1380 PMID: 28450357 04/30/2017    
  • Mitochondria-regulated formation of endothelium-derived extracellular vesicles shifts the mediator of flow-induced vasodilation. (Freed JK, Durand MJ, Hoffmann BR, Densmore JC, Greene AS, Gutterman DD) Am J Physiol Heart Circ Physiol 2017 May 01;312(5):H1096-H1104 PMID: 28213406 PMCID: PMC5451582 02/19/2017       3 Citations
  • Hypertension during Weight Lifting Reduces Flow-Mediated Dilation in Nonathletes. (Buchanan CE, Kadlec AO, Hoch AZ, Gutterman DD, Durand MJ) Med Sci Sports Exerc 2017 04;49(4):669-675 PMID: 27824690 PMCID: PMC5357152 11/09/2016       3 Citations
  • Does Barostress On The Endothelium During Maximal Exertion Cause Endothelial Dysfunction In Healthy, Sedentary Subjects?: 707 Board #23 June 1, 3: 30 PM - 5: 00 PM. (Durand MJ, Buchanan CE, Hoch AZ, Gutterman DD) Med Sci Sports Exerc 2016 May;48(5 Suppl 1):189-90 PMID: 27359850 07/01/2016    
  • Vascular Actions of Angiotensin 1-7 in the Human Microcirculation: Novel Role for Telomerase. (Durand MJ, Zinkevich NS, Riedel M, Gutterman DD, Nasci VL, Salato VK, Hijjawi JB, Reuben CF, North PE, Beyer AM) Arterioscler Thromb Vasc Biol 2016 06;36(6):1254-62 PMID: 27079876 PMCID: PMC4882242 04/16/2016       13 Citations
  • The Human Microcirculation: Regulation of Flow and Beyond. (Gutterman DD, Chabowski DS, Kadlec AO, Durand MJ, Freed JK, Ait-Aissa K, Beyer AM) Circ Res 2016 Jan 08;118(1):157-72 PMID: 26837746 PMCID: PMC4742348 02/04/2016       51 Citations
  • The Human Microcirculation Regulation of Flow and Beyond (David D. Gutterman, Dawid S. Chabowski, Andrew O. Kadlec, Matthew J. Durand, Julie K. Freed, Karima Ait-Aissa, Andreas M. Beyer) Circ Res 01/08/2016    
  • Critical Role for Telomerase in the Mechanism of Flow-Mediated Dilation in the Human Microcirculation. (Beyer AM, Freed JK, Durand MJ, Riedel M, Ait-Aissa K, Green P, Hockenberry JC, Morgan RG, Donato AJ, Peleg R, Gasparri M, Rokkas CK, Santos JH, Priel E, Gutterman DD) Circ Res 2016 Mar 04;118(5):856-66 PMID: 26699654 PMCID: PMC4772813 12/25/2015       29 Citations
  • Impaired Hyperemic Response to Exercise Post Stroke. (Durand MJ, Murphy SA, Schaefer KK, Hunter SK, Schmit BD, Gutterman DD, Hyngstrom AS) PLoS One 2015;10(12):e0144023 PMID: 26630380 PMCID: PMC4667998 12/03/2015       4 Citations
  • Acute exertion elicits a H2O2-dependent vasodilator mechanism in the microvasculature of exercise-trained but not sedentary adults. (Durand MJ, Dharmashankar K, Bian JT, Das E, Vidovich M, Gutterman DD, Phillips SA) Hypertension 2015 Jan;65(1):140-5 PMID: 25368025 PMCID: PMC4268168 11/05/2014       27 Citations
  • An acute rise in intraluminal pressure shifts the mediator of flow-mediated dilation from nitric oxide to hydrogen peroxide in human arterioles. (Beyer AM, Durand MJ, Hockenberry J, Gamblin TC, Phillips SA, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Dec 01;307(11):H1587-93 PMID: 25260615 PMCID: PMC4255007 09/28/2014       31 Citations
  • Exercise and vascular function: how much is too much? (Durand MJ, Gutterman DD) Can J Physiol Pharmacol 2014 Jul;92(7):551-7 PMID: 24873760 PMCID: PMC4398063 05/31/2014       10 Citations
  • The vascular renin-angiotensin system contributes to blunted vasodilation induced by transient high pressure in human adipose microvessels. (Durand MJ, Phillips SA, Widlansky ME, Otterson MF, Gutterman DD) Am J Physiol Heart Circ Physiol 2014 Jul 01;307(1):H25-32 PMID: 24778165 PMCID: PMC4080172 04/30/2014       12 Citations
  • Vascular dysfunction in diabetes mellitus: large conductance calcium-activated potassium channels as part of a subsarcolemmal signaling soiree. (Gutterman DD, Durand MJ) Circ Res 2014 Feb 14;114(4):588-90 PMID: 24526670 02/15/2014       3 Citations
  • Low-dose angiotensin II infusion restores vascular function in cerebral arteries of high salt-fed rats by increasing copper/zinc superoxide dimutase expression. (Durand MJ, Lombard JH) Am J Hypertens 2013 Jun;26(6):739-47 PMID: 23443725 PMCID: PMC3697069 02/28/2013       15 Citations
  • Diversity in mechanisms of endothelium-dependent vasodilation in health and disease. (Durand MJ, Gutterman DD) Microcirculation 2013 Apr;20(3):239-47 PMID: 23311975 PMCID: PMC3625248 01/15/2013       64 Citations
  • Acute and chronic angiotensin-(1-7) restores vasodilation and reduces oxidative stress in mesenteric arteries of salt-fed rats. (Raffai G, Durand MJ, Lombard JH) Am J Physiol Heart Circ Physiol 2011 Oct;301(4):H1341-52 PMID: 21803946 PMCID: PMC3197355 08/02/2011       37 Citations
  • Introgression of the Brown Norway renin allele onto the Dahl salt-sensitive genetic background increases Cu/Zn SOD expression in cerebral arteries. (Durand MJ, Lombard JH) Am J Hypertens 2011 May;24(5):563-8 PMID: 21331057 PMCID: PMC3285562 02/19/2011       13 Citations
  • Impaired relaxation of cerebral arteries in the absence of elevated salt intake in normotensive congenic rats carrying the Dahl salt-sensitive renin gene. (Durand MJ, Moreno C, Greene AS, Lombard JH) Am J Physiol Heart Circ Physiol 2010 Dec;299(6):H1865-74 PMID: 20852041 PMCID: PMC3006280 09/21/2010       15 Citations
  • Angiotensin-(1-7) and low-dose angiotensin II infusion reverse salt-induced endothelial dysfunction via different mechanisms in rat middle cerebral arteries. (Durand MJ, Raffai G, Weinberg BD, Lombard JH) Am J Physiol Heart Circ Physiol 2010 Oct;299(4):H1024-33 PMID: 20656887 PMCID: PMC2957344 07/27/2010       35 Citations
  • Angiotensin II maintains cerebral vascular relaxation via EGF receptor transactivation and ERK1/2. (McEwen ST, Balus SF, Durand MJ, Lombard JH) Am J Physiol Heart Circ Physiol 2009 Oct;297(4):H1296-303 PMID: 19684181 PMCID: PMC2770770 08/18/2009       13 Citations
  • Last update: 11/07/2018
    jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6