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Robert Lochhead PhD

Robert Lochhead PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Research Experience

  • Arthritis, Rheumatoid
  • Autoimmunity
  • Borrelia burgdorferi
  • Disease Models, Animal
  • Endothelial Cells
  • Fibroblasts
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Inflammation
  • Lyme Disease
  • Lymphocytes
  • MicroRNAs
  • Myeloid Cells
  • Myocarditis
  • Osteoarthritis, Knee
  • MCW Program / Core Facilities

  • Center for Infectious Disease Research
  • Educational Expertise

  • Microbiology
  • immunology
  • Publications

  • Lyme Disease-Associated IgG4 Autoantibodies Correlate with Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. (Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC) Arthritis Rheumatol 2018 May 23 PMID: 29790305 05/24/2018    
  • MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. (Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC) Arthritis Rheumatol 2017 05;69(5):1100-1110 PMID: 28076897 PMCID: PMC5406251 01/12/2017       2 Citations
  • Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. (Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ) PLoS One 2015;10(8):e0135142 PMID: 26252010 PMCID: PMC4529177 08/08/2015       7 Citations
  • Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production. (Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ) J Immunol 2014 Dec 15;193(12):6050-60 PMID: 25378596 PMCID: PMC4258437 11/08/2014       5 Citations
  • MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. (Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ) PLoS Pathog 2014 Jun;10(6):e1004212 PMID: 24967703 PMCID: PMC4072785 06/27/2014       15 Citations
  • Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. (Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ) J Immunol 2012 Sep 01;189(5):2488-501 PMID: 22851707 PMCID: PMC3424307 08/02/2012       12 Citations
  • Quorum sensing primes the oxidative stress response in the insect endosymbiont, Sodalis glossinidius. (Pontes MH, Babst M, Lochhead R, Oakeson K, Smith K, Dale C) PLoS One 2008;3(10):e3541 PMID: 18958153 PMCID: PMC2568817 10/30/2008       21 Citations
  • Last update: 08/17/2018
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