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Robert Lochhead PhD

Robert Lochhead PhD

Assistant Professor

Institution: Medical College of Wisconsin
Department: Microbiology and Immunology

Member of the Cardiovascular Center

Research Experience

  • Arthritis, Rheumatoid
  • Autoimmunity
  • Borrelia burgdorferi
  • Disease Models, Animal
  • Endothelial Cells
  • Fibroblasts
  • Gene Expression Regulation
  • Host-Pathogen Interactions
  • Inflammation
  • Lyme Disease
  • Lymphocytes
  • MicroRNAs
  • Myeloid Cells
  • Myocarditis
  • Osteoarthritis, Knee
  • MCW Program / Core Facilities

  • Center for Infectious Disease Research
  • Educational Expertise

  • Microbiology
  • immunology
  • Publications

  • Interferon-gamma production in Lyme arthritis synovial tissue promotes differentiation of fibroblast-like synoviocytes into immune effector cells. (Lochhead RB, Ordoñez D, Arvikar SL, Aversa JM, Oh LS, Heyworth B, Sadreyev R, Steere AC, Strle K) Cell Microbiol 2019 Feb;21(2):e12992 PMID: 30550623 12/15/2018    
  • Robust interferon signature and suppressed tissue repair gene expression in synovial tissue from patients with postinfectious, Borrelia burgdorferi-induced Lyme arthritis. (Lochhead RB, Arvikar SL, Aversa JM, Sadreyev RI, Strle K, Steere AC) Cell Microbiol 2019 Feb;21(2):e12954 PMID: 30218476 09/16/2018    
  • Correlation of Lyme Disease-Associated IgG4 Autoantibodies With Synovial Pathology in Antibiotic-Refractory Lyme Arthritis. (Sulka KB, Strle K, Crowley JT, Lochhead RB, Anthony R, Steere AC) Arthritis Rheumatol 2018 Nov;70(11):1835-1846 PMID: 29790305 PMCID: PMC6203610 05/24/2018       1 Citations
  • MicroRNA Expression Shows Inflammatory Dysregulation and Tumor-Like Proliferative Responses in Joints of Patients With Postinfectious Lyme Arthritis. (Lochhead RB, Strle K, Kim ND, Kohler MJ, Arvikar SL, Aversa JM, Steere AC) Arthritis Rheumatol 2017 05;69(5):1100-1110 PMID: 28076897 PMCID: PMC5406251 01/12/2017       4 Citations
  • Antagonistic Interplay between MicroRNA-155 and IL-10 during Lyme Carditis and Arthritis. (Lochhead RB, Zachary JF, Dalla Rosa L, Ma Y, Weis JH, O'Connell RM, Weis JJ) PLoS One 2015;10(8):e0135142 PMID: 26252010 PMCID: PMC4529177 08/08/2015       8 Citations
  • Borrelia burgdorferi arthritis-associated locus Bbaa1 regulates Lyme arthritis and K/B×N serum transfer arthritis through intrinsic control of type I IFN production. (Ma Y, Bramwell KK, Lochhead RB, Paquette JK, Zachary JF, Weis JH, Teuscher C, Weis JJ) J Immunol 2014 Dec 15;193(12):6050-60 PMID: 25378596 PMCID: PMC4258437 11/08/2014       7 Citations
  • MicroRNA-146a provides feedback regulation of lyme arthritis but not carditis during infection with Borrelia burgdorferi. (Lochhead RB, Ma Y, Zachary JF, Baltimore D, Zhao JL, Weis JH, O'Connell RM, Weis JJ) PLoS Pathog 2014 Jun;10(6):e1004212 PMID: 24967703 PMCID: PMC4072785 06/27/2014       17 Citations
  • Endothelial cells and fibroblasts amplify the arthritogenic type I IFN response in murine Lyme disease and are major sources of chemokines in Borrelia burgdorferi-infected joint tissue. (Lochhead RB, Sonderegger FL, Ma Y, Brewster JE, Cornwall D, Maylor-Hagen H, Miller JC, Zachary JF, Weis JH, Weis JJ) J Immunol 2012 Sep 01;189(5):2488-501 PMID: 22851707 PMCID: PMC3424307 08/02/2012       15 Citations
  • Quorum sensing primes the oxidative stress response in the insect endosymbiont, Sodalis glossinidius. (Pontes MH, Babst M, Lochhead R, Oakeson K, Smith K, Dale C) PLoS One 2008;3(10):e3541 PMID: 18958153 PMCID: PMC2568817 10/30/2008       23 Citations
  • Last update: 01/10/2019
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