Medical College of Wisconsin
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Diabetes and depression: global perspectives. Diabetes Res Clin Pract 2010 Mar;87(3):302-12 PMID: 20181405

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BACKGROUND: Diabetes and depression are highly prevalent conditions and have significant impact on health outcomes. This study reviewed the literature on the prevalence, burden of illness, morbidity, mortality, and cost of comorbid depression in people with diabetes as well as the evidence on effective treatments.

METHODS: Systematic review of the literature on the relationship between diabetes and depression was performed. A comprehensive search of the literature was performed on Medline from 1966 to 2009. Studies that examined the association between diabetes and depression were reviewed. A formal meta-analysis was not performed because of the broad area covered and the heterogeneity of the studies. Instead, a qualitative aggregation of studies was performed.

RESULTS: Diabetes and depression are debilitating conditions that are associated with significant morbidity, mortality, and healthcare costs. Coexisting depression in people with diabetes is associated with decreased adherence to treatment, poor metabolic control, higher complication rates, decreased quality of life, increased healthcare use and cost, increased disability and lost productivity, and increased risk of death.

CONCLUSION: The coexistence of diabetes and depression is associated with significant morbidity, mortality, and increased healthcare cost. Coordinated strategies for clinical care are necessary to improve clinical outcomes and reduce the burden of illness.

Author List

Egede LE, Ellis C


Leonard E. Egede MD Center Director, Chief, Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-77649190271   248 Citations

MESH terms used to index this publication - Major topics in bold

Depressive Disorder
Diabetes Mellitus
Global Health
Health Care Costs
Health Services
Life Style
Quality of Health Care
Quality of Life
Self Care
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e