Eosinophilic Kidney Tumors: Old and New. Arch Pathol Lab Med 2019 Dec;143(12):1455-1463
Date
08/14/2019Pubmed ID
31403331DOI
10.5858/arpa.2019-0203-RAScopus ID
2-s2.0-85075812682 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
CONTEXT.—: Eosinophilic cytoplasm is the most common finding of difficult-to-classify kidney tumors. Morphology, cytogenetics, and immunohistochemical stains are discriminatory. This review compares well-recognized tumors such as granular clear cell carcinoma, papillary variants, chromophobe renal cell carcinoma, and oncocytoma and introduces newly described entities of hybrid oncocytic tumors, carcinomas defined by translocations, and carcinomas with deficiencies in the tricarboxylic acid cycle. The focus is on immunostaining, clinical correlations, and differential diagnoses. Representative examples of some entities are presented with elaboration on their workup.
OBJECTIVE.—: To provide a review of the differential diagnoses for renal neoplasms with eosinophilic cytoplasm and elaborate on methods that may assist with correct identification.
DATA SOURCES.—: Review of current literature on kidney tumors with eosinophilic cytoplasm, as well as the authors' personal experience.
CONCLUSIONS.—: Eosinophilic cytoplasm is a feature shared by many kidney tumors. Understanding the morphologic differences and the role of ancillary studies is key when encountering such a tumor.
Author List
Iczkowski KA, Czaja RCAuthor
Rebecca Claire Czaja MD Instructor in the Pathology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Eosine Yellowish-(YS)Humans
Immunohistochemistry
Kidney Neoplasms
Staining and Labeling
