Cyclobenzaprine effects on locus coeruleus cells in tissue slice. Neuropharmacology 1983 Feb;22(2):249-52
Date
02/01/1983Pubmed ID
6835493DOI
10.1016/0028-3908(83)90017-5Scopus ID
2-s2.0-0020647152 (requires institutional sign-in at Scopus site) 5 CitationsAbstract
Tissue slices 400 mu thick were taken from the brain stem, at the level of the locus coeruleus, of 150-250 g Sprague-Dawley rats. Microelectrodes were placed in the locus coeruleus under visual control, and a cell whose discharge rate would decrease with microiontophoretic application of norepinephrine or clonidine was sought. Cyclobenzaprine (CBZ) was then introduced into the perfusion medium at a concentration equivalent to 1 mg/kg body weight of the whole animal. Discharge rates before and during CBZ administration were compared. The six cells with initial discharge rates between 2 and 10 Hz decreased firing with CBZ, whereas the four cells with initial rates between 0.5 and 1.5 Hz increased their rates with CBZ.
Author List
Lang IM, Barnes CDAuthor
Ivan M. Lang DVM, PhD Adjunct Professor in the Medicine department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
Action PotentialsAmitriptyline
Animals
Clonidine
Electric Stimulation
In Vitro Techniques
Locus Coeruleus
Male
Norepinephrine
Rats
Rats, Inbred Strains
