Faculty Collaboration Database

Long-term results of treatment studies for childhood acute lymphoblastic leukemia: Pediatric Oncology Group studies from 1986-1994. Leukemia 2000 Dec;14(12):2276-85

Date

02/24/2001

Pubmed ID

11187919

DOI

10.1038/sj.leu.2401965

Scopus ID

2-s2.0-0034525194 (requires institutional sign-in at Scopus site)   87 Citations

Abstract

This paper presents the long-term results of treatment for children with acute lymphoblastic leukemia (ALL) as conducted by the Pediatric Oncology Group (POG) from 1986 to 1994. The data are presented using standard NCI/Rome risk criteria. The overall event-free survival (EFS) at 5 and 10 years were 70.9% and 67.3% for children with B-precursor ALL, 51.0% and 50.2% for patients with T cell ALL, and 22.4% and 20.9% for infants with ALL. Concomitant biologic studies found that in B-precursor ALL a DNA index (DI) of > or =1.16 and trisomies of both chromosomes 4 and 10 were good prognostic indicators for patients with B-precursor ALL. The traditional prognostic indicators (age and white count), DI and trisomies did not predict outcome in patients with T cell disease. Infants continued to do poorly overall despite more intensive therapy with rotating pairs of chemotherapy. We recommend continued reporting of study results using common risk criteria in order to facilitate comparisons both within and across study groups.

Author List

Maloney KW, Shuster JJ, Murphy S, Pullen J, Camitta BA

MESH terms used to index this publication - Major topics in bold

Antineoplastic Combined Chemotherapy Protocols
Child
Child, Preschool
Disease-Free Survival
Female
Humans
Infant
Male
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Recurrence