Medical College of Wisconsin
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Role of human papillomavirus in cutaneous oncogenesis. Ann Plast Surg 1994 Sep;33(3):339-47 PMID: 7985976

Pubmed ID

7985976

Abstract

There is a strong association between the human papillomavirus and cutaneous squamous cell carcinoma. If this association was merely random, one would expect an equal distribution of human papillomavirus types among affected individuals. However, only specific types of human papillomavirus are consistently found in cutaneous and genital squamous cell carcinomas. Immunosuppressed individuals clearly have a much higher incidence of cutaneous carcinomas. Immunosuppression, either local or systemic, not only decreases immune surveillance but may also dictate the amount and type of virus each individual may carry. Epidermodysplasia verruciformis and other rare hereditary disorders that combine specific immune defects and an increased incidence of malignancy are very useful models that clearly fulfill a multistep theory of oncogenesis. The precise mechanism of oncogenesis in these select human papillomavirus types is not yet fully understood. Intracellular interactions with the recently described tumor suppressor proteins may prove to be the primary site of action of these oncogenic viruses. Environmental cocarcinogens and activation of oncogenes are clearly important if not essential factors in human papillomavirus-associated tumors. As our knowledge and understanding of malignant transformation grows, it becomes apparent that this is a complex multistep process.

Author List

Drolet BA, Neuburg M, Sanger J



Scopus

2-s2.0-0028023839   14 Citations

MESH terms used to index this publication - Major topics in bold

Carcinoma, Squamous Cell
Cocarcinogenesis
Epidermodysplasia Verruciformis
Female
Genital Diseases, Female
Humans
Immunocompromised Host
Keratoacanthoma
Papillomaviridae
Skin Neoplasms
Tumor Virus Infections
jenkins-FCD Prod-331 a335b1a6d1e9c32173c9534e6f6ff51494143916