Medical College of Wisconsin
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The effects of hypovolemia on multiple organ injury following intestinal reperfusion. Shock 1994 Jun;1(6):408-12 PMID: 7735969

Pubmed ID



This study examines the relationship between hypovolemia and remote organ injury following intestinal reperfusion. Sprague-Dawley rats underwent intestinal ischemia (120 min) and reperfusion (90 min, IIR) or sham operation (CTL). The animals received normal saline (NS) at 0, 30, or 40 ml/kg/h intravenously. Lung and intestinal injury was quantitated using an edema index, and liver injury was assessed by measuring bile flow rates. The infusion of 40 ml/kg/h of NS attenuated the intestinal edema index of IIR animals nearly 50% (p < .05). Despite this improvement, this parameter remained nearly 10-fold greater than that of CTL (p < .05). The lung edema index was 70% greater in IIR animals receiving 30 and 40 ml/kg/h of NS than those not receiving NS. The infusion of 40 ml/kg/h of NS restored bile flow rates in IIR animals to that of CTL. These data suggest that hypovolemia may contribute to the intestinal and hepatic injury in this model. The lung injury is independent of hypovolemia.

Author List

Turnage RH, Guice KS, Oldham KT


Keith T. Oldham MD Professor in the Surgery department at Medical College of Wisconsin


2-s2.0-0028457837   19 Citations

MESH terms used to index this publication - Major topics in bold

Blood Volume
Multiple Trauma
Pulmonary Edema
Rats, Sprague-Dawley
Reperfusion Injury
jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad