Faculty Collaboration Database

Results of bone marrow transplants from human leukocyte antigen-identical sibling donors for treatment of childhood leukemias. A report from the International Bone Marrow Transplant Registry. Am J Pediatr Hematol Oncol 1993 Feb;15(1):56-64 PMID: 8383476

Pubmed ID

8383476

Abstract

PURPOSE: Bone marrow transplantation is an effective treatment for leukemia. Cures are possible in 20-80% of transplant recipients depending on the stage of leukemia at the time of transplant. The antileukemia efficacy of transplants result from high-dose chemotherapy and/or radiation given pretransplant and from immune-mediated effects of the graft.

RESULTS: Success of the procedure is limited by transplant-related complications, including graft rejection, graft-vs.-host disease and interstitial pneumonia. Five-year leukemia-free survival ranges from approximately 25% for children transplanted with advanced leukemia, to > 60% in those transplanted in first remission of acute leukemia or first chronic phase of chronic myeloid leukemia.

CONCLUSIONS: Candidates for transplant include children failing conventional therapy and, possibly, those with early leukemia characterized by features predicting a poor response to conventional therapy.

Author List

Horowitz MM, Bortin MM

Author

Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin

Scopus

2-s2.0-0027409794   17 Citations

MESH terms used to index this publication - Major topics in bold

Actuarial Analysis
Anemia, Aplastic
Bone Marrow Transplantation
Child
Combined Modality Therapy
Cytomegalovirus Infections
Genetic Diseases, Inborn
Graft Rejection
Graft vs Host Disease
HLA Antigens
Humans
International Cooperation
Leukemia
Leukemia, Myelogenous, Chronic, BCR-ABL Positive
Leukemia, Myeloid, Acute
Nuclear Family
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pulmonary Fibrosis
Registries
Remission Induction
Survival Analysis
Transplantation, Homologous
Treatment Outcome