Does indomethacin attenuate the coronary vasodilatory effect of nitroglycerin? J Am Coll Cardiol 1984 Dec;4(6):1114-7
Date
12/01/1984Pubmed ID
6438204DOI
10.1016/s0735-1097(84)80129-1Abstract
Although previous studies have shown that indomethacin attenuates the dilative effects of nitroglycerin on human peripheral veins and canine coronary arteries, its ability to alter the influence of nitroglycerin on coronary blood flow in human beings is unknown. In 22 patients (16 men and 6 women, aged 47 +/- 10 years [mean +/- standard deviation]) referred for the evaluation of chest pain, heart rate, systemic arterial pressure, coronary sinus blood flow (by thermodilution) and coronary vascular resistance (mean arterial pressure/coronary sinus blood flow) were measured before and during the administration of intracoronary saline solution (n = 6, [control subjects]) or intracoronary nitroglycerin, 100 micrograms (n = 16). Of these 16 patients, 8 had no pretreatment and the other 8 received 50 mg of indomethacin orally, 10 and 2 to 3 hours before study. In the six control subjects, no variable changed with saline injection. In the eight patients given nitroglycerin without indomethacin pretreatment, heart rate and mean systemic arterial pressure were changed modestly (72 +/- 15 to 74 +/- 15 beats/min and 93 +/- 9 to 87 +/- 13 mm Hg, respectively, p less than 0.05), coronary sinus blood flow increased by 56 +/- 43% (107 +/- 72 to 155 +/- 78 ml/min, p less than 0.001) and coronary vascular resistance decreased (1.12 +/- 0.50 to 0.66 +/- 0.26 mm Hg/ml per min, p = 0.004).(ABSTRACT TRUNCATED AT 250 WORDS)
Author List
Winniford MD, Jackson J, Malloy CR, Rehr RB, Campbell WB, Hillis LDAuthor
William B. Campbell PhD Professor in the Pharmacology and Toxicology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AdultAged
Blood Pressure
Coronary Circulation
Coronary Vessels
Female
Heart Rate
Humans
Indomethacin
Male
Middle Aged
Nitroglycerin
Vascular Resistance
Vasodilation
