Medical College of Wisconsin
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The clinical diagnosis of acute graft-versus-host disease: a diversity of views amongst marrow transplant centers. Bone Marrow Transplant 1988 Jan;3(1):5-10 PMID: 3048470

Pubmed ID



The diagnosis and grading of acute graft-versus-host disease (AGVHD) is based on a spectrum of clinical and laboratory features. To evaluate the reliability of current diagnostic and scoring criteria, six clinical vignettes were evaluated by 49 transplant physicians from 42 bone marrow transplant center worldwide. Responses were analysed to determine: (1) the degree of concordance among transplanters in diagnosing, scoring and treating AGVHD, and (2) the degree of concordance in assigning primary and contributing causes of death in patients with multiple complications of bone marrow transplantation. Concordance for the diagnosis of AGVHD ranged from 24 to 76%; concordance for grading AGVHD was 55%. Concordance for the decision to treat for AGVHD ranged from 43 to 55%; concordance for assigning the primary cause of death ranged from 71 to 100%. The findings demonstrate the need for (1) improved uniformity of reporting complications of bone marrow transplantation; (2) periodic revision and validation of diagnostic and grading criteria, and (3) methods of analysis that allow for multiple causes of death.

Author List

Atkinson K, Horowitz MM, Biggs JC, Gale RP, Rimm AA, Bortin MM


Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin


2-s2.0-0023830925   32 Citations

MESH terms used to index this publication - Major topics in bold

Acute Disease
Bone Marrow Transplantation
Cause of Death
Graft vs Host Disease
Pulmonary Fibrosis
Skin Diseases
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6