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Juvenile xanthogranuloma. J Am Acad Dermatol 1997 Mar;36(3 Pt 1):355-67; quiz 368-9 PMID: 9091465

Pubmed ID



Juvenile xanthogranuloma (JXG) is a benign, self-healing disorder characterized by solitary or multiple yellow-red nodules on the skin and, occasionally, in other organs. It is predominantly a disease of infancy or early childhood, although adults may also be affected. Histologically, JXG represents an accumulation of histiocytes lacking Birbeck granules (non-Langerhans cells), which can be differentiated from Langerhans cells by specific staining techniques. Affected persons have normal lipid metabolism. JXG is therefore classified as a normolipemic non-Langerhans cell histiocytosis. The patient's general health is not impaired and, in the absence of associated conditions, the prognosis is excellent. Diagnosis is readily made in typical cases, but may be more difficult in unusual variants.

Author List

Hernandez-Martin A, Baselga E, Drolet BA, Esterly NB


Beth A. Drolet MD Professor in the Dermatology department at Medical College of Wisconsin


2-s2.0-0030946360   189 Citations

MESH terms used to index this publication - Major topics in bold

Diagnosis, Differential
Xanthogranuloma, Juvenile
jenkins-FCD Prod-297 dff1a717c492f00bf6291286365f1f4fe95208f1