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The differential effects of GABA-transaminase inactivation in the chick retina and brain. J Neurochem 1982 Oct;39(4):1147-51 PMID: 7119785

Pubmed ID

7119785

Abstract

The inactivation of gamma-aminobutyrate (GABA)-transaminase by the highly specific and potent neurotoxin gabaculine leads to different neurochemical consequences in the chick brain as opposed to the chick retina. In the brain, GABA levels continually climb, reaching approximately eightfold increases over control values after 24 h. The elevation in GABA levels leads to a time-dependent and coincident fall in glutamate decarboxylase and cysteine-sulfinate decarboxylase activities, to approximately 50% of control values. On the other hand, in the retina GABA levels only increase to a plateau level two- to threefold that of control after inactivation of GABA-transaminase. Furthermore, although the glutamate decarboxylase activity decreases to about 50% of control values, cysteinesulfinate decarboxylase activity is not affected. These studies show that the processing of GABA in the retina differs from that in the brain, and that cysteinesulfinate and glutamate decarboxylase activity probably reside in different enzyme molecules in the retina, although they may reside in the same enzyme in the brain.

Author List

Rando RR, Coburn J, Parkinson D

Author

Jenifer Coburn PhD Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0020364643   4 Citations

MESH terms used to index this publication - Major topics in bold

4-Aminobutyrate Transaminase
Animals
Brain
Chickens
Cyclohexanecarboxylic Acids
Glutamate Decarboxylase
Retina
Time Factors
Transaminases
gamma-Aminobutyric Acid
jenkins-FCD Prod-332 f92a19b0ec5e8e1eff783fac390ec127e367c2b5