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Nephromegaly and elevated hepatocyte growth factor in children with biliary atresia. Am J Kidney Dis 1997 Feb;29(2):188-92

Date

02/01/1997

Pubmed ID

9016888

DOI

10.1016/s0272-6386(97)90028-7

Abstract

Nephromegaly, a rarely mentioned but probably common situation, was studied in children with biliary atresia. We evaluated the length and the cross-sectional diameters of the kidney by ultrasound in 21 children with biliary atresia as well as in 50 healthy children. The ages ranged from 1 month to 10 years. Plasma hepatocyte growth factor (HGF) was measured in 18 children with biliary atresia and also in 18 age- and sex-matched normal controls. There was a significant nephromegaly (increase in the renal length and the kidney volume) in children with biliary atresia as compared with normal children (P < 0.001 by analysis of covariance). Plasma HGF levels were elevated in these patients (2.13 +/- 1.06 v 0.76 +/- 0.19 ng/mL in controls, P < 0.001) and had a positive correlation with the renal size after considering the effect of body height by multiple regression analysis (P = 0.0022 for renal length, and P < 0.001 for kidney volume). These results confirm the presence of large kidneys in biliary atresia and implicate the possible pathogenic role of HGF in such a condition. Nephromegaly in biliary atresia may provide a new in vivo model to study the mechanism of renal growth.

Author List

Tsau YK, Chen CH, Chang MH, Teng RJ, Lu MY, Lee PI

Author

Ru-Jeng Teng MD Associate Professor in the Pediatrics department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Biliary Atresia
Body Height
Child
Child, Preschool
Female
Hepatocyte Growth Factor
Humans
Infant
Kidney
Male
Regression Analysis
Ultrasonography
jenkins-FCD Prod-398 336d56a365602aa89dcc112f077233607d6a5abc