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Plasticity of respiratory rhythm-generating mechanisms in adult goats. Adv Exp Med Biol 2010;669:151-5

Date

03/11/2010

Pubmed ID

20217339

DOI

10.1007/978-1-4419-5692-7_30

Scopus ID

2-s2.0-77952299480   3 Citations

Abstract

Abrupt destruction of >70% of the pre-Bötzinger complex (preBötzC) in awake goats results in terminal apnea (Wenninger et al. 2004b). Herein we report data on awake and sleeping goats in which the preBötzC was incrementally destroyed by injection of ibotenic acid (IBO) in increasing volumes at weekly intervals. All injections resulted in an acute tachypnea and dysrhythmia featuring apneas and increased variation in breathing. In studies at night, 10-15 hours after the injections, apneas were nearly all central and occurred during the awake state and variation in breathing was greater while awake than during NREM sleep. However, one week after the final IBO injection, the breathing pattern, breath-to-breath variation, and arterial blood gases were unchanged from baseline, indicating recovery. Histology revealed more than 90% destruction of the preBötzC region, and greater than 80% destruction of the surrounding area. We conclude: (1) the dysrhythmic effects on breathing acutely after the injection are state-dependent, and (2) after incremental, near-complete destruction of the preBötzC region, time-dependent plasticity within the respiratory network provides a normal respiratory rhythm that sustains normal arterial blood gases.

Author List

Forster HV, Krause KL, Kiner T, Neumueller SE, Bonis JM, Qian B, Pan LG

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Animals
Arteries
Blood Gas Analysis
Goats
Ibotenic Acid
Neuronal Plasticity
Neurons
Periodicity
Receptors, Neurokinin-1
Respiratory Mechanics
Wakefulness
jenkins-FCD Prod-399 190a069c593fb5498b7fcd942f44b7bc9cdc7ea1