Medical College of Wisconsin
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Elastic laminae in vascular development and disease. Mol Cell Biomech 2010 Jun;7(2):59-76 PMID: 20936740

Pubmed ID



The activities of vascular cells, including adhesion, proliferation, and migration, are mediated by extracellular matrix components, including collagen matrix and elastic fibers or laminae. Whereas the collagen matrix stimulates vascular cell adhesion, proliferation, and migration, the elastic laminae inhibit these activities. Coordinated regulation of cell activities by these matrix components is an essential process for controlling the development and remodeling of the vascular system. This article summarizes recent development on the role of arterial elastic laminae in regulating the development of smooth muscle-like cells from bone marrow-derived progenitor cells as well as in mediating cell adhesion, proliferation, and migration with a focus on the molecular mechanisms and physiological significance.

Author List

Liu SQ, Teft BJ, Zhang LQ, Li YC, Wu YH


Brandon J. Tefft PhD Assistant Professor in the Biomedical Engineering department at Medical College of Wisconsin


2-s2.0-77952976642   3 Citations

MESH terms used to index this publication - Major topics in bold

Antigens, CD34
Biomechanical Phenomena
Blood Vessels
Bone Marrow Cells
Cell Adhesion
Cell Movement
Cell Proliferation
Elastic Tissue
Myocytes, Smooth Muscle
Protein Tyrosine Phosphatase, Non-Receptor Type 6
Vascular Diseases
jenkins-FCD Prod-336 69ef4a6b262d135130251597d5d39873903802b5