Important role of carotid chemoreceptor afferents in control of breathing of adult and neonatal mammals. Respir Physiol 2000 Feb;119(2-3):199-208
Date
03/21/2000Pubmed ID
10722863DOI
10.1016/s0034-5687(99)00115-2Scopus ID
2-s2.0-0034102480 (requires institutional sign-in at Scopus site) 66 CitationsAbstract
This review provides a summary and prospective on the importance of carotid/peripheral chemoreceptors to the control of breathing during physiologic conditions. For several days after carotid body denervation (CBD), adult mammals hypoventilate (+10 mmHg increase in Pa(CO(2))) at rest and during exercise and CO(2) sensitivity is attenuated by about 60%. In addition, if the rostral ventrolateral medulla is cooled during NREM sleep after CBD, a sustained apnea is observed. Eventually, days or weeks after CBD, a peripheral ventilatory chemoreflex redevelops and there is a normalization of breathing (rest and exercise) and CO(2) sensitivity. The site (s) of the regained chemosensitivity has not been established. This plasticity/redundancy after CBD appears greater in neonates than in adult mammals. These data suggest the carotid and other peripheral chemoreceptors provide an important excitatory input to medullary respiratory neurons that is essential for breathing when wakeful stimuli and central chemoreceptors are absent.
Author List
Forster HV, Pan LG, Lowry TF, Serra A, Wenninger J, Martino PAuthor
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AgingAnimals
Animals, Newborn
Carotid Body
Chemoreceptor Cells
Humans
Infant, Newborn
Neurons, Afferent
Respiratory Mechanics