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Important role of carotid chemoreceptor afferents in control of breathing of adult and neonatal mammals. Respir Physiol 2000 Feb;119(2-3):199-208

Date

03/21/2000

Pubmed ID

10722863

DOI

10.1016/s0034-5687(99)00115-2

Scopus ID

2-s2.0-0034102480   50 Citations

Abstract

This review provides a summary and prospective on the importance of carotid/peripheral chemoreceptors to the control of breathing during physiologic conditions. For several days after carotid body denervation (CBD), adult mammals hypoventilate (+10 mmHg increase in Pa(CO(2))) at rest and during exercise and CO(2) sensitivity is attenuated by about 60%. In addition, if the rostral ventrolateral medulla is cooled during NREM sleep after CBD, a sustained apnea is observed. Eventually, days or weeks after CBD, a peripheral ventilatory chemoreflex redevelops and there is a normalization of breathing (rest and exercise) and CO(2) sensitivity. The site (s) of the regained chemosensitivity has not been established. This plasticity/redundancy after CBD appears greater in neonates than in adult mammals. These data suggest the carotid and other peripheral chemoreceptors provide an important excitatory input to medullary respiratory neurons that is essential for breathing when wakeful stimuli and central chemoreceptors are absent.

Author List

Forster HV, Pan LG, Lowry TF, Serra A, Wenninger J, Martino P

Author

Hubert V. Forster PhD Professor in the Physiology department at Medical College of Wisconsin




MESH terms used to index this publication - Major topics in bold

Aging
Animals
Animals, Newborn
Carotid Body
Chemoreceptor Cells
Humans
Infant, Newborn
Neurons, Afferent
Respiratory Mechanics
jenkins-FCD Prod-399 190a069c593fb5498b7fcd942f44b7bc9cdc7ea1