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The emerging role for rat models in gene discovery. Mamm Genome 2011 Aug;22(7-8):466-75 PMID: 21732192 PMCID: PMC3643810

Pubmed ID

21732192

Abstract

Rat models have been used for many decades to study physiological and pathophysiological mechanisms. Prior to the release of the rat genome and new technologies for targeting gene manipulation, the rat had been the underdog in the genomics era, despite the abundance of physiological data compared to the mouse. The overarching goal of biomedical research is to improve health and advance medical science. Translating human disease gene discovery and validation in the rat, through the use of emerging technologies and integrated tools and databases, is providing power to understand the genetics, environmental influences, and biology of disease. In this review we briefly outline the rat models, bioinformatics tools, and technologies that are changing the landscape of translational research. The strategies used to translate disease traits to genes to function, and, ultimately, to improve human health is discussed. Finally, our perspective on how rat models will continue to positively impact biomedical research is provided.

Author List

Dwinell MR, Lazar J, Geurts AM

Authors

Melinda R. Dwinell PhD Center Associate Director, Associate Professor in the Physiology department at Medical College of Wisconsin
Aron Geurts PhD Associate Professor in the Physiology department at Medical College of Wisconsin




Scopus

2-s2.0-80051552900   19 Citations

MESH terms used to index this publication - Major topics in bold

Animals
Computational Biology
Databases, Nucleic Acid
Genetic Association Studies
Genetics, Medical
Humans
Models, Animal
Rats
jenkins-FCD Prod-300 626508253d14e4184314fb9f66322a03a5906796