Effect of carotid body denervation on breathing in neonatal goats. J Appl Physiol (1985) 1999 Sep;87(3):1026-34
Date
09/14/1999Pubmed ID
10484573DOI
10.1152/jappl.1999.87.3.1026Scopus ID
2-s2.0-0032882533 (requires institutional sign-in at Scopus site) 16 CitationsAbstract
The objective of the present study was to determine in goats whether carotid body denervation (CBD) at 1-3 days of age causes permanent changes in breathing greater than those that occur after CBD in adult goats. Goats underwent CBD (n = 6) or sham CBD (n = 3) surgery at 1-3 days of age. In addition, one unoperated control animal was studied. Bolus intravenous injections of NaCN 2 days postsurgery verified successful CBD surgery. However, at 3, 11, and 18 mo of age, the CBD goats had regained a NaCN response that did not differ (P > 0.10) from that of intact goats. Intracarotid NaCN injections elicited a hyperpnea in the sham CBD but not the CBD goats. Only one animal exhibited highly irregular breathing [characterized by prolonged (>9-s) apneas] after CBD, and the irregularity disappeared by 3 mo of age. One CBD goat died at 35 days of age, and autopsy revealed that death was associated with pneumonia. After 3 mo of age, there were no statistically significant differences (P > 0.10) between sham and CBD goats in eupneic breathing, hypoxia and CO(2) sensitivity, and the exercise hyperpnea. It is, therefore, concluded that CBD at 1-3 days of age in goats does not appear to affect selected aspects of respiratory control after 3 mo of age, conceivably because of the emergence of other functional chemoreceptors that compensate for the loss of the carotid chemoreceptor.
Author List
Lowry TF, Forster HV, Pan LG, Korducki MA, Probst J, Franciosi RA, Forster MAuthor
Hubert V. Forster PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsAnimals, Newborn
Blood Gas Analysis
Blood Pressure
Carotid Body
Denervation
Goats
Heart Rate
Hypercapnia
Hypoxia
Neurons, Afferent
Physical Exertion
Respiratory Mechanics
Time Factors
