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Toxicity of high-dose cytosine arabinoside in the treatment of advanced childhood tumors resistant to conventional therapy. A Pediatric Oncology Group study. Cancer 1990 Nov 15;66(10):2064-7 PMID: 2224760

Pubmed ID

2224760

Abstract

Experience with high-dose cytosine arabinoside (HDAC) in pediatric solid tumors is limited. Sixteen children with solid tumors resistant to conventional therapies were registered in a pilot Pediatric Oncology Group (POG) study that required the administration of HDAC at 3 g/m2 every 12 hours for four doses. There were four cases of rhabdomyosarcoma, two cases of fibrosarcoma, four cases of neuroblastoma, and one case each of germ cell tumor, Wilm's tumor, retinoblastoma, hepatocellular carcinoma, Ewing's sarcoma, and Burkitt's lymphoma. All eligible patients had advanced diseases and had previously received extensive chemotherapy. Thirteen patients received one course of HDAC and three patients received two courses of HDAC. Due to prior treatments, patients had less than normal marrow reserves. Short-term toxicity included nausea, vomiting, suppression of hemopoiesis, drug fever, and increased blood urea nitrogen (BUN), creatinine, and liver enzymes. All evaluable patients recovered from their toxicities. There were no drug-related deaths. None of the patients had neurologic problems, including the only patient with prior irradiation to the skull. With the above schedule, HDAC appears to have manageable toxicity.

Author List

Tebbi CK, Krischer J, Fernbach DJ, Mahoney DH, Alvarado C, Camitta B

Author

Bruce M. Camitta MD Clinical Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-0025202711   4 Citations

MESH terms used to index this publication - Major topics in bold

Child
Cytarabine
Drug Administration Schedule
Fibrosarcoma
Humans
Infusions, Intravenous
Nausea
Neoplasms
Neuroblastoma
Pilot Projects
Rhabdomyosarcoma
Vomiting
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e