Mapping baroreceptor function to genome: a mathematical modeling approach. Genetics 2002 Apr;160(4):1687-95
Date
04/26/2002Pubmed ID
11973321Pubmed Central ID
PMC1462065DOI
10.1093/genetics/160.4.1687Scopus ID
2-s2.0-0036236799 (requires institutional sign-in at Scopus site) 11 CitationsAbstract
To gain information about the genetic basis of a complex disease such as hypertension, blood pressure averages are often obtained and used as phenotypes in genetic mapping studies. In contrast, direct measurements of physiological regulatory mechanisms are not often obtained, due in large part to the time and expense required. As a result, little information about the genetic basis of physiological controlling mechanisms is available. Such information is important for disease diagnosis and treatment. In this article, we use a mathematical model of blood pressure to derive phenotypes related to the baroreceptor reflex, a short-term controller of blood pressure. The phenotypes are then used in a quantitative trait loci (QTL) mapping study to identify a potential genetic basis of this controller.
Author List
Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ, Tonellato PJAuthor
Allen W. Cowley Jr PhD Professor in the Physiology department at Medical College of WisconsinMESH terms used to index this publication - Major topics in bold
AnimalsBaroreflex
Blood Pressure
Chromosome Mapping
Genome
Humans
Models, Genetic
Pressoreceptors
Quantitative Trait, Heritable
