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Mapping baroreceptor function to genome: a mathematical modeling approach. Genetics 2002 Apr;160(4):1687-95 PMID: 11973321 PMCID: PMC1462065

Abstract

To gain information about the genetic basis of a complex disease such as hypertension, blood pressure averages are often obtained and used as phenotypes in genetic mapping studies. In contrast, direct measurements of physiological regulatory mechanisms are not often obtained, due in large part to the time and expense required. As a result, little information about the genetic basis of physiological controlling mechanisms is available. Such information is important for disease diagnosis and treatment. In this article, we use a mathematical model of blood pressure to derive phenotypes related to the baroreceptor reflex, a short-term controller of blood pressure. The phenotypes are then used in a quantitative trait loci (QTL) mapping study to identify a potential genetic basis of this controller.

Author List

Kendziorski CM, Cowley AW Jr, Greene AS, Salgado HC, Jacob HJ, Tonellato PJ

Authors

Allen W. Cowley Jr PhD Chair, Professor in the Physiology department at Medical College of Wisconsin
Andrew S. Greene PhD Interim Vice Chair, Chief, Professor in the Biomedical Engineering department at Medical College of Wisconsin
Peter Tonellato PhD Professor in the School of Public Health department at University of Wisconsin - Milwaukee

MESH terms used to index this publication - Major topics in bold

Animals
Baroreflex
Blood Pressure
Chromosome Mapping
Genome
Humans
Models, Genetic
Pressoreceptors
Quantitative Trait, Heritable



View this publication's entry at the Pubmed website PMID: 11973321
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