Application of physiological genomics to the microcirculation. Microcirculation 2002 Jan;9(1):3-12
Date
03/16/2002Pubmed ID
11896555DOI
10.1038/sj.mn.7800117Scopus ID
2-s2.0-0036368669 (requires institutional sign-in at Scopus site) 8 CitationsAbstract
Physiological genomics represents a new challenge in the biological sciences-the quest to define the functions of thousands of genes that will emerge from the sequencing of the human genome and the genomes of other model organisms. Because the attention of the scientific community has focused on this task, new tools that will allow high-efficiency identification of gene function are being developed at remarkable speed. Physiological genomic approaches to understanding integrated systems function are now becoming widely used in many areas of biological research. The availability of genomic information across species has now revealed a striking degree of conservation of both gene order and function, allowing researchers to easily move from model organisms to man in the hunt for gene function. Physiological genomics approaches in the cardiovascular system have focused on disease-based models and the behavior of large vessels. In the microcirculation, genomic studies have largely been confined to the use of single gene knockouts or to the study of angiogenesis. This review summarizes the strategies for physiological genomics that are appropriate to the study of the microcirculation and discusses several key discoveries that have been made by using these approaches.
Author List
Greene ASMESH terms used to index this publication - Major topics in bold
AnimalsGenes
Genetic Predisposition to Disease
Genetic Techniques
Genomics
Humans
Microcirculation
Neovascularization, Pathologic
