Medical College of Wisconsin
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Hormones and radiation therapy in locally advanced adenocarcinoma of the prostate. Semin Radiat Oncol 2003 Apr;13(2):141-51 PMID: 12728443

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Hormonal dependency of prostate cancer was first described in 1895 by White who showed the initial observation between castration and the treatment of prostatic disease in men with bladder outlet obstruction secondary to benign prostatic hypertrophy. Subsequently, in 1940 Huggins and Hodges demonstrated the association between normal and hyperplastic epithelium of canine prostate glands and adequate levels of circulating androgens. This pioneering work led extensive investigation of the role of androgens in both prostatic growth for benign and malignant disease. The goal of this article is to review the role of hormonal manipulation in prostate cancer in general and more specifically to focus on the role of radiation therapy and hormonal manipulation in locally advanced adenocarcinoma of the prostate. The article is divided into sections that outline the role of different types of hormonal manipulation that are currently available along with the early work combining hormonal manipulation and radiation therapy for prostate cancer. Subsequently, a thorough review of the phase III trials performed to evaluate the potential role of hormonal manipulation in addition to radiation therapy in locally advanced adenocarcinoma of the prostate. Included in that discussion is a section on the potential toxicities of hormonal manipulation. Finally, the current recommendations for the use of hormonal manipulation combined with radiation therapy in locally advanced adenocarcinoma of the prostate is described.

Author List

Lawton CA


Colleen A. Lawton MD Vice Chair, Professor in the Radiation Oncology department at Medical College of Wisconsin


2-s2.0-0038304594   9 Citations

MESH terms used to index this publication - Major topics in bold

Androgen Antagonists
Antineoplastic Agents, Hormonal
Clinical Trials, Phase III as Topic
Combined Modality Therapy
Neoplasm Recurrence, Local
Prostatic Neoplasms
Radiotherapy, Adjuvant
jenkins-FCD Prod-353 9ccd8489072cb19f5b9f808bb23ed672c582f41e