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Stem cell donation--what advice can be given to the donor? Br J Haematol 2009 Oct;147(1):71-6 PMID: 19681886 PMCID: PMC3409390

Pubmed ID

19681886

Abstract

Haematopoietic stem cell transplantation (HSCT) is widely used to treat patients with a range of haematological and non-haematological disorders. Both bone marrow and peripheral blood stem cell collection are associated with morbidity and, very rarely, mortality. We investigated the information that exists to adequately inform donors about the relative merits of each procedure. We carried out a systematic review analysing data from six prospective randomised controlled trials of related donors and discuss here the merits and drawbacks of this approach. Registry data mostly describes patient outcome but stem cell donor registries collect and report information on unrelated donors which could easily be extended to related donors. Further well-designed, randomised studies are required.

Author List

Pamphilon D, Siddiq S, Brunskill S, Dorée C, Hyde C, Horowitz M, Stanworth S

Author

Mary M. Horowitz MD, MS Center Director, Professor in the Medicine department at Medical College of Wisconsin




Scopus

2-s2.0-70349203764   9 Citations

MESH terms used to index this publication - Major topics in bold

Donor Selection
Evidence-Based Medicine
Health Education
Hematopoietic Stem Cell Transplantation
Humans
Randomized Controlled Trials as Topic
Registries
Tissue Donors
Tissue and Organ Harvesting
jenkins-FCD Prod-299 9ef562391eceb2b8f95265c767fbba1ce5a52fd6