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Molecular biology and immunology of fungal allergens. Indian J Clin Biochem 2000 Aug;15(Suppl 1):31-42 PMID: 23105266 PMCID: PMC3454084

Abstract

Fungi are non-chlorophyllus microorganisms, which constitutes the main source of outdoor and indoor allergens. The antigens present in the spores and fragments of hyphae induce allergic responses in sensitized patients. The frequently recognized fungi associated with asthma include Alternaria, Cladosporium, Aspergillus, and Penicillium. With the advent of molecular biology techniques a number of fungal genes encoding relevant allergens have been cloned and the expressed allergens purified and characterized. In this review, we have presented the recent developments, where recombinant allergens have been used in the precise diagnosis of fungal allergy. We have also discussed the role played by these allergens and the T- and B-cell epitopes in the immune mechanism in fungal allergy.

Author List

Kurup VP, Banerjee B, Kelly KJ, Fink JN

Author

Banani Banerjee PhD Associate Professor in the Medicine department at Medical College of Wisconsin



View this publication's entry at the Pubmed website PMID: 23105266
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