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Effect of chronic treatment with deoxycorticosterone acetate on content of a natriuretic substance in atria of rats. Proc Soc Exp Biol Med 1986 Oct;183(1):92-8 PMID: 2944121

Pubmed ID



Chronic (72 days) administration of deoxycorticosterone acetate (DOCA), with or without saline as the sole drinking fluid, depleted atria of rats of their diuretic and natriuretic activities. Chronic ingestion of saline as the sole drinking fluid did not affect the diuretic, natriuretic, and kaliuretic activities of atria compared with those of rats receiving water to drink. Since systolic blood pressure of the DOCA-treated group did not differ significantly from that of the untreated control group, the decrease in potency of atrial extract from DOCA-treated rats most likely occurred in response to increases in extracellular and vascular volumes. The ability of DOCA to decrease diuretic and natriuretic activities of atria was dose dependent. The decreased activities of the atria of DOCA-treated rats could reflect an increased production and turnover of atrial natriuretic factor. Additional studies revealed an increased diuretic and natriuretic responsiveness of DOCA-treated recipients to atrial extract from untreated rats. Thus, the results of these studies suggest that chronic treatment with DOCA reduced the natriuretic and diuretic potencies of atrial extract and increased renal responsiveness to it.

Author List

Hathaway SJ, Fregly MJ, Wilson KM, Papanek PE, Henley WN


Paula Papanek PhD, MPT, LAT, FACSM Associate Professor & Director of Exercise Science in the Exercise Science & Physical Therapy department at Marquette University


2-s2.0-0022443868   1 Citations

MESH terms used to index this publication - Major topics in bold

Atrial Natriuretic Factor
Biological Assay
Heart Atria
Rats, Inbred Strains
jenkins-FCD Prod-310 bff9d975ec7f2d302586822146c2801dd4449aad